Cas 1366595-48-3,C18H22N2O4

1366595-48-3

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Basic information

Product Name: C₁₈H₂₂N₂O₄
Synonyms: C₁₈H₂₂N₂O₄
CAS NO:1366595-48-3
Molecular Formula:
Molecular Weight: 330.384
EINECS: N/A
Product Categories: N/A

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: N/A
Density: N/A
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: C₁₈H₂₂N₂O₄(CAS DataBase Reference)
NIST Chemistry Reference: C₁₈H₂₂N₂O₄(1366595-48-3)
EPA Substance Registry System: C₁₈H₂₂N₂O₄(1366595-48-3)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 1366595-48-3(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 1366595-48-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,6,6,5,9 and 5 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1366595-48:
(9*1)+(8*3)+(7*6)+(6*6)+(5*5)+(4*9)+(3*5)+(2*4)+(1*8)=203
203 % 10 = 3
So 1366595-48-3 is a valid CAS Registry Number.

1366595-48-3Upstream product

851544-48-4 (3aS,5R,7aS,9aS)-3-benzyl-4-oxo-decahydro-2-oxa-3,4a-diazacyclopenta[f]azulene-5-carboxylic acid tert-butyl ester

1366595-48-3Downstream Products

1366595-48-3Relevant academic research and scientific papers

Dual action Smac mimetics–zinc chelators as pro-apoptotic antitumoral agents

Manzoni, Leonardo,Gornati, Davide,Manzotti, Mattia,Cairati, Silvia,Bossi, Alberto,Arosio, Daniela,Lecis, Daniele,Seneci, Pierfausto

, p. 4613 - 4619 (2016)

Dual action compounds (DACs) based on 4-substituted aza-bicyclo[5.3.0]decane Smac mimetic scaffolds (ABDs) linked to a Zn2+-chelating moiety (DPA, o-hydroxy, m-allyl, N-acyl (E)-phenylhydrazone) through their 10 position are reported and characterized. Their synthesis, their target affinity (XIAP BIR3, Zn2+) in cell-free assays, their pro-apoptotic effects and cytotoxicity in tumor cells with varying sensitivity to Smac mimetics are described. The results are interpreted to evaluate the influence of Zn2+chelators on cell-free potency and on cellular permeability of DACs, and to propose novel avenues towards more potent antitumoral DACs based on Smac mimetics and Zn2+chelation.

4-Connected azabicyclo[5.3.0]decane Smac mimetics-Zn2+ chelators as dual action antitumoral agents

Manzoni, Leonardo,Samela, Alessandro,Barbini, Stefano,Cairati, Silvia,Penconi, Marta,Arosio, Daniela,Lecis, Daniele,Seneci, Pierfausto

supporting information, p. 2336 - 2344 (2017/05/10)

Putative dual action compounds (DACs 3a–d) based on azabicyclo[5.3.0]decane (ABD) Smac mimetic scaffolds linked to Zn2+-chelating 2,2′-dipicolylamine (DPA) through their 4 position are reported and characterized. Their synthesis, their target a

Rational design, synthesis and characterization of potent, drug-like monomeric Smac mimetics as pro-apoptotic anticancer agents

Bianchi, Aldo,Ugazzi, Marcello,Ferrante, Luca,Lecis, Daniele,Scavullo, Cinzia,Mastrangelo, Eloise,Seneci, Pierfausto

supporting information; experimental part, p. 2204 - 2208 (2012/04/18)

A set of phenyl-substituted Smac mimetics/IAP inhibitor analogues of lead compound 2a was synthesized, aiming to retain its strong cell-free potency while increasing its bioavailability. Seventeen compounds 2b-r were prepared and characterized in vitro, u

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