1099616-09-7

Basic information

• Product Name: C₁₉H₂₄N₂O₄
• Synonyms: C₁₉H₂₄N₂O₄
• CAS NO: 1099616-09-7
• Molecular Weight: 344.411
• Mol File: 1099616-09-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: C₁₉H₂₄N₂O₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₉H₂₄N₂O₄(1099616-09-7)
• EPA Substance Registry System: C₁₉H₂₄N₂O₄(1099616-09-7)

Safety Data

• Hazardous Substances Data: 1099616-09-7(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 1366595-48-3 C₁₈H₂₂N₂O₄ 
• 851544-48-4 (3aS,5R,7aS,9aS)-3-benzyl-4-oxo-decahydro-2-oxa-3,4a-diazacyclopenta[f]azulene-5-carboxylic acid tert-butyl ester 

Downstream Products

• 1608150-84-0 methyl 11-((S)-2-((3S,6S,7R,9aS)-7-(2-benzamidoethyl)-6-((S)-2-(methylamino)butanamido)-5-oxooctahydro-1H-pyrrolo[1,2-a]azepine-3-carboxamido)-2-phenylacetamido)undecanoate hydrochloride 
• 1608150-80-6 11-((S)-2-((3S,6S,7R,9aS)-7-(2-benzamidoethyl)-6-((R)-2-((tertbutoxycarbonyl)(methyl)amino)butanamido)-5-oxooctahydro-1H-pyrrolo[1,2-a]azepine-3-carboxamido)-2-phenylacetamido)undecanoic acid 
• 1608150-83-9 methyl 11-((S)-2-((3S,6S,7R,9aS)-7-(2-benzamidoethyl)-6-((R)-2-((tert-butoxycarbonyl)(methyl)amino)butanamido)-5-oxooctahydro-1H-pyrrolo[1,2-a]azepine-3-carboxamido)-2-phenylacetamido)undecanoate 
• 1608150-75-9 (3S,6S,7R,9aS)-7-(2-benzamidoethyl)-6-((R)-2-((tert-butoxycarbonyl)(methyl)amino)butanamido)-5-oxooctahydro-1H-pyrrolo-[1,2-a]azepine-3-carboxylic acid 
• 1608150-79-3 (3S,6S,7R,9aS)-methyl 7-(2-benzamidoethyl)-6-((R)-2-((tert-butoxycarbonyl)(methyl)amino)butanamido)-5-oxooctahydro-1H-pyrrolo[1,2-a]azepine-3-carboxylate 

Relevant articles and documents

Dual action Smac mimetics–zinc chelators as pro-apoptotic antitumoral agents

Dual action compounds (DACs) based on 4-substituted aza-bicyclo[5.3.0]decane Smac mimetic scaffolds (ABDs) linked to a Zn2+-chelating moiety (DPA, o-hydroxy, m-allyl, N-acyl (E)-phenylhydrazone) through their 10 position are reported and characterized. Their synthesis, their target affinity (XIAP BIR3, Zn2+) in cell-free assays, their pro-apoptotic effects and cytotoxicity in tumor cells with varying sensitivity to Smac mimetics are described. The results are interpreted to evaluate the influence of Zn2+chelators on cell-free potency and on cellular permeability of DACs, and to propose novel avenues towards more potent antitumoral DACs based on Smac mimetics and Zn2+chelation.

NEW SMAC MIMETIC COMPOUNDS AS APOPTOSIS INDUCERS

The present invention relates to compounds conformationally constrained mimetics of Smac with function as inhibitors of Inhibitor of Apoptosis Proteins (IAPs), the invention also relates to the use of these compounds in therapy, wherein the induction of a