136663-23-5

Basic information

• Product Name: 6-Benzoxazolecarboxylic acid, 2-Methyl-, Methyl ester
• Synonyms: methyl 2-methylbenzo[d]oxazole-6-carboxylate;6-Benzoxazolecarboxylic acid, 2-Methyl-, Methyl ester;Methyl 2-Methyl-1,3-benzoxazole-6-carboxylate
• CAS NO: 136663-23-5
• Molecular Formula: C₁₀H₉NO₃
• Molecular Weight: 191.18336
• Mol File: 136663-23-5.mol
• Article Data: 13

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-Benzoxazolecarboxylic acid, 2-Methyl-, Methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Benzoxazolecarboxylic acid, 2-Methyl-, Methyl ester(136663-23-5)
• EPA Substance Registry System: 6-Benzoxazolecarboxylic acid, 2-Methyl-, Methyl ester(136663-23-5)

Safety Data

• Hazardous Substances Data: 136663-23-5(Hazardous Substances Data)

Usage

Uses

Methyl 2-Methylbenzo[d]oxazole-6-carboxylate is a reactant that is useful for the synthesis of SB-?334867 (I) analogs. SB-?334867 is an orexin antagonist.

Upstream product

• 1445-45-0 Trimethyl orthoacetate 
• 63435-16-5 3-hydroxy-4-aminobenzoic acid methyl ester 
• 2208-07-3 ethyl acetimidate hydrochloride 
• 144-55-8 sodium hydrogencarbonate 
• 75-36-5 acetyl chloride 
• 78-39-7 Triethyl orthoacetate 
• 713-52-0 methyl 3-hydroxy-4-nitrobenzoate 
• 91-66-7 N,N-diethylaniline 
• 39267-53-3 methyl 4-acetamido-3-hydroxybenzoate 

Downstream Products

• 13452-14-7 2-methyl-6-benzoxazole carboxylic acid 
• 136663-40-6 (2-methyl-1,3-benzoxazol-6-yl)methanol 
• 792173-99-0 1-(2-methylbenzoxazol-6-yl)-3-(1,5-naphthyridin-4-yl)urea 
• 864274-04-4 2-methyl-1,3-benzoxazole-6-carbaldehyde 
• 10098-40-5 4-acetamido-3-hydroxybenzoic acid 

Relevant articles and documents

Hydrolytic instability of the important orexin 1 receptor antagonist SB-334867: Possible confounding effects on in vivo and in vitro studies

SB-334867 has been an important ligand for the study of the orexin 1 (OX1) receptor due to its high OX1/OX2 selectivity and bioavailability. This ligand however, contains a 2-methylbenzoxazole ring system which is known to undergo hydrolysis, particularly under acidic or basic conditions. The possibility that SB-334867 would be susceptible to significant hydrolysis was evaluated in various formulations and in the solid state. SB-334867 was found to be unstable under conditions commonly employed to prepare stock solutions for in vitro and in vivo studies. In addition, and most alarmingly, the hydrochloride salt of SB-334867 was found to quantitatively decompose to an OX1-inactive product even in the solid state. These findings combine to suggest that studies using SB-334867 (and any other 2-methylbenzoxazole-containing compound) should be performed with great care to avoid the confounding effects of the rapid hydrolytic decomposition of this susceptible structure.

NOVEL ANTIMALARIA AGENT CONTAINING HETEROCYCLIC COMPOUND

Disclosed is an antimalarial agent containing a compound represented by the formula: [wherein A1 represents a 3-pyridyl group that may have a substituent, a 6-quinolyl group that may have a substituent, or the like; X1 represents a group represented by the formula -C(=O)-NH- or the like; E represents a furyl group, a thienyl group or a phenyl group; with the proviso that A1 may have one to three substituents, and E has one of two substituents] or a salt thereof or hydrates thereof.

BENZAMIDE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE

The invention relates to the inhibition of histone deacetylase. The invention provides compounds which are derivatives of benzamide and suitable in methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions .