136668-22-9

Upstream product

• 1147550-11-5 ammonium thiocyanate 
• 541-41-3 chloroformic acid ethyl ester 
• 134-20-3 2-carbomethoxyaniline 
• 16182-04-0 Ethoxycarbonyl isothiocyanate 

Downstream Products

• 1310739-45-7 3-(2,6-dichlorobenzyl)-2-ethoxycarbonylaminoquinazolin-4(3H)-one 
• 1310739-47-9 2-ethoxycarbonylamino-3-phenylquinazolin-4(3H)-one 
• 1310739-48-0 3-(2-carbomethoxyphenyl)-2-ethoxycarbonylaminoquinazolin-4(3H)-one 
• 1310739-49-1 2-ethoxycarbonylamino-3-(3-nitrophenyl)quinazolin-4(3H)-one 
• 1310739-44-6 3-benzyl-2-ethoxycarbonylaminoquinazolin-4(3H)-one 

Relevant academic research and scientific papers

Aminopyrazine Pathway to the Moco Metabolite Dephospho Form A

An efficient synthesis of the molybdopterin/molybdenum cofactor (Moco) oxidation product dephospho Form A is described that assembles the pteridinone system starting from an iodinated aminopyrazine. The sodium salt of dephospho Form A could be purified by precipitation from methanol, which paved the way to the title compound in the 100 mg range. By HPLC, the synthetic material was compared with a sample isolated from a recombinant Moco containing protein. Analysis of dephospho Form A is the only method that allows the quantification of the Moco content of crude cell extracts and recombinant protein preparations.

Solvent induced geometry transformation of trigonal planar Cu(I) complexes of N-((2/4-methyoxy carbonyl) phenyl)-N′-(ethoxy/methoxy carbonyl) thiocarbamides to square-planar Cu(II) complexes: Synthesis, spectral, single crystal, DFT and in vitro cytotoxic

Complexation between copper(II) chloride and three newly synthesized ligands, (N-((2/4-methyoxy carbonyl) phenyl)-N′-(ethoxy carbonyl) thiocarbamides (2/4-MCPET)(1, 2) and (N-(2-methyoxy carbonyl phenyl)-N′-(methoxy carbonyl) thiocarbamide (2-MCPMT)(3) af

Efficient room-temperature one-pot synthesis of 2-amino-3-alkyl(3-aryl) quinazolin-4(3H)-ones

Starting from anthranilates, the one-pot successive addition of ethoxycarbonylisothiocyanate, alkyl- or arylamines, and the coupling reagent EDCI led to the clean, room-temperature formation of carbamate-protected 2-amino-3-alkyl(3-aryl)quinazolin-4(3H)-ones in up to 93% yield. This method provides a practical alternative to previously reported procedures for the synthesis of 2-amino-3-substituted quinazolin-4(3H)-ones.