136727-13-4

Usage

Uses

Used in Pharmaceutical Industry:
2-Quinoxalinemethanamine, N-methyl-(9CI) is used as a building block in the synthesis of various drugs and bioactive compounds for the treatment of different diseases and conditions.
Used in Organic Synthesis:
2-Quinoxalinemethanamine, N-methyl-(9CI) is used as a reagent or intermediate in the synthesis of complex organic molecules, contributing to the development of new chemical entities with potential applications in various fields.
Used in Research and Development:
2-Quinoxalinemethanamine, N-methyl-(9CI) is used as a research compound for the investigation of its properties, reactivity, and potential applications in the development of new therapeutic agents and chemical entities.

InChI:InChI=1/C10H11N3/c1-11-6-8-7-12-9-4-2-3-5-10(9)13-8/h2-5,7,11H,6H2,1H3

Upstream product

• 54804-43-2 2-(bromomethyl)quinoxaline 
• 74-89-5 methylamine 
• 91-19-0 2,3-diethynylquinoxaline 
• 7251-61-8 2-methylquinoxaline 

Downstream Products

• 137898-32-9 N-<4-<2-hydroxy-3-propoxy>phenyl>methanesulfonamide 
• 136727-14-5 2-<methylamino>methyl>quinoxaline 
• 136727-16-7 2-[N-[3-(4-Aminophenoxy)propyl]methylamino methyl]quinoxaline 
• 136727-09-8 N-<4-<3-propoxy>phenyl>methanesulfonamide 

Relevant academic research and scientific papers

Introduction of Quinolines and Isoquinolines onto Nonactivated α-C-H Bond of Tertiary Amides through a Radical Pathway

Treatment of quinolines and isoquinolines with benzoyl peroxide in tertiary amides, such as N,N-dimethylacetamide, N,N-dimethylpropionamide, and N-acetylpyrrolidine, etc., under irradiation with a Hg lamp in the temperature range of 35 °C to 40 °C gave C-C-bonded quinolines and isoquinolines bearing amide groups with high regioselectivity in good to moderate yields, respectively, under transition-metal-free conditions.

N-quinolinyl alkyl-substituted 1-aryloxy-2-propanolamine and propylamine derivatives possessing class III antiarrhythmic activity

This invention relates to N-heteroalkyl-substituted 1-aryloxy-2-propanolamine and propylamine derivatives possessing anti-arrhythmic activity, to pharmaceutical compositions and to methods for production thereof.

Substituted benzimidazole derivatives possessing Class III antiarrhythmic activity

This invention relates to N-heteroalkyl-substituted 1-aryloxy-2-propanolamine and proplyamine derivatives possessing anti-arrhythmic activity, to pharmaceutical compositions and to method for production thereof.

Synthesis and Selective Class III Antiarrhythmic Activity of Novel N-Heteroaralkyl-Substituted 1-(Aryloxy)-2-propanolamine and Related Propylamine Derivatives

The synthesis and biological evaluation of a series of novel 1-(aryloxy)-2-propanolamines and several related deshydroxy analogues are described.Compounds 4-29 were prepared and investigated for their class III electrophysiological activity in isolated canine Purkinje fibers and in anesthetized open-chest dogs.None of these compounds showed any class I activity.On the basis of the in vitro data, structure-activity relationships for the series are discussed.Two compounds, N-propoxy>phenyl>methanesulfonamide (12, WAY-123,223) and N-phenoxy>propyl>amino>methyl>-6-quinolinyl>methanesulfonamide (24, WAY-125,971) were identified and characterized as potent and specific class III antiarrhythmic agents in vitro and in vivo.Compound 12 was found to be orally bioavailable, to produce large increases of ventricular fibrillation threshold (VFT), and, in some instances, to restore sinus rhythm from ventricular fibrillation in anesthetized open-chest dogs at a dose of 5 mg/kg (iv).The enantiomers of 12 (i.e., 13 and 14) were synthesized and were found to exhibit similar electrophysiological effects in the Purkinje fiber screen.Compound 24, a propylamine analogue with potency and efficacy comparable to those of UK-68798 (2) and E-4031 (3), was studied in voltage-clamp experiments (isolated cat myocytes) and was found to be a potent and specific blocker of the delayed rectifier potassium current (IK).