136741-00-9

Upstream product

• 118227-48-8 (2R,4R)-2,4-diacetoxy-1,5-dichloro-3-pentanol 
• 100-39-0 benzyl bromide 
• 1053624-50-2 (2S,4S)-1,5-di-O-(2,4,6-triisopropylbenzenesulfonyl)-arabitol 
• 7643-75-6 L-(-)-arabitol 

Downstream Products

• 118227-50-2 (4S,6S)-5-Benzyloxy-1,9-diethoxy-nona-1,8-diyne-4,6-diol 
• 870294-67-0 (2R,3R,4S)-[3-benzyloxy-4-(tert-butyldimethylsilyloxy)-2-hydroxymethyl]cyclopentan-1-one-1,3-propanedithioketal 
• 870294-72-7 (1S,2S)-1-benzyloxy-3-(2-tert-butyldimethylsilanyl-1,3-dithian-2-yl)-1-((1S)-oxiranyl)propan-2-ol 
• 870294-71-6 (2R,3S,4S)-[3-benzyloxy-4-(tert-butyldimethylsilyloxy)-2-trityloxymethyl]cyclopentan-1-one-1,3-propanedithioketal 
• 870294-70-5 (2R,3R,4S)-[3-benzyloxy-4-(tert-butyldimethylsilyloxy)-2-trityloxymethyl]cyclopentan-1-one-1,3-propanedithioketal 

Relevant academic research and scientific papers

A convenient synthesis of N-substituted trihydroxypiperidines from bis- epoxides: Nucleophilic opening of 1,2:4,5-dianhydropentitols

Synthesis of a number of N-substituted trihydroxypiperidine and trihydroxypyrrolidines is described via the nucleophilic opening and cyclisation of suitable bis-epoxides. Reaction conditions to maximise the yield of the trihydroxypiperidine products forme

Improved synthesis of enantiopure pseudo-C2-symmetric 1,4-bis-epoxide building blocks from arabitol

An improved large-scale synthesis of 1,2:4,5-dianhydro-3-benzylarabitol and 1,2:4,5-dianhydroarabitol from arabitol is described.