A convenient synthesis of N-substituted trihydroxypiperidines from bis- epoxides: Nucleophilic opening of 1,2:4,5-dianhydropentitols

DOI: 10.1055/s-2000-6499

Source and publish data:

Synlett p. 193 - 196 (2000)

Update date:2022-07-29

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Authors:

Smith, Rachel D.

Thomas, Neil R.

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Article abstract of DOI:10.1055/s-2000-6499

Synthesis of a number of N-substituted trihydroxypiperidine and trihydroxypyrrolidines is described via the nucleophilic opening and cyclisation of suitable bis-epoxides. Reaction conditions to maximise the yield of the trihydroxypiperidine products forme

Full text of DOI:10.1055/s-2000-6499

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Product name:(2S,4S)-1,2:4,5-dianhydro-3-(benzyl)arabitol

Cas No:136741-00-9

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