Antitumor agents. II: Regio- and stereospecific syntheses of 1-β-alkyl-1-desoxypodophyllotoxin derivatives and biological activity

DOI: 10.1248/cpb.41.907

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 907 - 912 (1993)

Update date:2022-08-04

Topics:

Authors:

Terada Terada

Fujimoto

Nomura Nomura

Yamashita

Wierzba Wierzba

Kobunai Kobunai

Takeda Takeda

Minami Minami

Yoshida Yoshida

Yamaguchi

Yamada Yamada

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Article abstract of DOI:10.1248/cpb.41.907

1-β-Alkyl derivatives of 1-desoxypodophyllotoxin were synthesized, and their cytotoxicity and inhibitory effects on DNA topoisomerase II (Topo-II) and tubulin polymerization were examined. The reaction of epipodophyllotoxin derivatives (1a-c) with trimeth

Full text of DOI:10.1248/cpb.41.907

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