136773-58-5

Basic information

• Product Name: 1-[2-NITRO-4-(TRIFLUOROMETHYL)PHENYL]-1H-PYRROLE
• Synonyms: 1-[2-NITRO-4-(TRIFLUOROMETHYL)PHENYL]-1H-PYRROLE;1-[2-NITRO-4-(TRIFLUOROMETHYL)PHENYL]-1H-PYRROLE: TECH.;1-[2-Nitro-5-(trifluoromethyl)phenyl]-1H-pyrrole
• CAS NO: 136773-58-5
• Molecular Formula: C₁₁H₇F₃N₂O₂
• Molecular Weight: 256.18
• Mol File: 136773-58-5.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 309.8±42.0 °C(Predicted)
• Appearance: /
• Density: 1.40±0.1 g/cm3(Predicted)
• PKA: -6.66±0.70(Predicted)
• CAS DataBase Reference: 1-[2-NITRO-4-(TRIFLUOROMETHYL)PHENYL]-1H-PYRROLE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[2-NITRO-4-(TRIFLUOROMETHYL)PHENYL]-1H-PYRROLE(136773-58-5)
• EPA Substance Registry System: 1-[2-NITRO-4-(TRIFLUOROMETHYL)PHENYL]-1H-PYRROLE(136773-58-5)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 136773-58-5(Hazardous Substances Data)

Usage

Structure

Contains a pyrrole ring with a nitro and trifluoromethyl group attached to a phenyl ring

Applications

Used in organic synthesis and medicinal chemistry for the development of pharmaceuticals and agrochemicals

Potential applications

May have potential applications in materials science and electronics due to its unique chemical structure and properties

Safety

Important to handle with care as it may have harmful effects on human health and the environment

Upstream product

• 109-97-7 pyrrole 
• 367-86-2 1-fluoro-2-nitro-4-trifluoromethyl-benzene 
• 121-17-5 2-chloro-3-nitro-5-trifluoromethylbenzene 
• 696-59-3 cis,trans-2,5-dimethoxytetrahydrofuran 
• 400-98-6 4-trifluoromethyl-2-nitroaniline 

Downstream Products

• 1259379-37-7 C₂₄H₁₉F₃N₄O 
• 664997-07-3 2-[4-(7-trifluoromethyl-pyrrolo[1,2-a]quinoxalin-4-ylmethoxy)-benzoylamino]-pentanedioic acid diethyl ester 
• 664996-66-1 4-(7-trifluoromethyl-pyrrolo[1,2-a]quinoxalin-4-ylmethoxy)-benzoic acid ethyl ester 
• 664997-27-7 2-chloro-N-[(5-trifluoromethyl-pyrrol-1-yl)phenyl]acetamide 
• 664997-23-3 5–trifluoromethyl–2–(1H–pyrrol–1–yl)aniline 
• 136773-65-4 1-<2-nitro-4-(trifluoromethyl)phenyl>-1H-pyrrole-2-carboxamide 
• 136773-68-7 4-Chloro-7-trifluoromethyl-pyrrolo[1,2-a]quinoxaline 
• 109028-09-3 7-trifluoromethyl-4-(4-methyl-1-piperazinyl)pyrolo[1,2-a]quinoxaline 

Relevant articles and documents

Synthesis of oxazolidinones through ring-opening and annulation of vinylene carbonate with 2-pyrrolyl/indolylanilines under Rh(iii) catalysis

Herein, we have developed a rhodium-catalyzed C-H functionalization and subsequent intramolecular ring-opening/cyclization of vinylene carbonate with 2-pyrrolyl/indolylanilines, which leads to oxazolidinones in moderate to good yields. In this transformation, vinylene carbonate only eliminates one oxygen atom rather than -CO3 or CO2. Furthermore, some control experiments are conducted to elucidate the reaction mechanism. This journal is

Ruthenium-Catalyzed Synthesis of Pyrrolo[1,2- A [quinoxaline Derivatives from 1-(2-Aminophenyl)pyrroles and Sulfoxonium Ylides

A ruthenium-catalyzed [5+1] annulation of 1-(2-aminophenyl)pyrroles with α-carbonyl sulfoxonium ylides is reported. This reaction provides a one-step method for synthesizing pyrrolo[1,2- A [quinoxaline derivatives under ambient conditions. The system proceeds with a short reaction time and a high functional-group tolerance. Notably, this divergent protocol tolerates β-keto sulfoxonium ylides and can be applied to α-ester sulfoxonium ylides. A preliminary study was made of the mechanism of the reaction, and a reaction pathway is proposed.

TFAA-Catalyzed Annulation Synthesis of Spiro Pyrrolo[1,2-a]quinoxaline Derivatives from 1-(2-Aminophenyl)pyrroles and Benzoquinones/Ketones

A metal-free trifluorosulfonate anhydride (TFAA)-catalyzed strategy for the synthesis of spiro pyrrolo[1,2-a]quinoxalines from 1-(2-aminophenyl)pyrroles and benzoquinones/ketones has been developed. With this general method, spiro pyrrolo[1,2-a]quinoxalin