13682-25-2Relevant articles and documents
Organocatalyzed solvent free an efficient novel synthesis of 2,4,5-trisubstituted imidazoles for α-glucosidase inhibition to treat diabetes
Yar, Muhammad,Bajda, Marek,Shahzad, Sohail,Ullah, Nisar,Gilani, Mazhar Amjad,Ashraf, Muhammad,Rauf, Abdul,Shaukat, Ayesha
, p. 65 - 71 (2015)
A new and efficient solvent free synthesis of 2,4,5-trisubstituted imidazoles (3a-3j) was achieved by N-acetyl glycine (NAG) catalyzed three components condensation of aldehydes, benzil and ammonium acetate. Our synthetic methodology accommodated a range of various substituted alkyl and aryl aldehydes. Evaluation of α-glucosidase inhibitory activity of these imidazole derivatives revealed that most of them presented good α-glucosidase inhibition at low micro-molar concentrations. Among the synthesized compounds, compound 3c, bearing the ortho-hydroxy phenyl substituent at position 2 displayed the highest inhibitory activity with an IC50 value 74.32 ± 0.59 μM. In silico molecular docking for all compounds and computational studies of the most active compound 3c were also performed.
Living ring-opening polymerization of lactones by n-heterocyclic Olefin/Al(C6F5)3 lewis pairs: Structures of intermediates, kinetics, and mechanism
Wang, Qianyi,Zhao, Wuchao,He, Jianghua,Zhang, Yuetao,Chen, Eugene Y.-X.
, p. 123 - 136 (2017)
The strong Lewis acid Al(C6F5)3, in combination with a strong Lewis base N-heterocyclic olefin (NHO), cooperatively promotes the living ring-opening (co)- polymerization of lactones, represented by δ-valerolactone (δ-VL) and ?-caprolactone (?-CL) in this
Metal-free, acid-promoted synthesis of imidazole derivatives via a multicomponent reaction
Chen, Chung-Yu,Hu, Wan-Ping,Yan, Pi-Cheng,Senadi, Gopal Chandru,Wang, Jeh-Jeng
supporting information, p. 6116 - 6119 (2014/01/17)
An expedient and metal-free synthetic route has been developed for the construction of tri- and tetrasubstituted imidazole derivatives via acid promoted multicomponent reaction methodology. The reaction proceeded smoothly with a range of functionalities to produce the imidazole scaffolds in good to excellent yields.