136834-21-4

Basic information

• Product Name: Adenosine, N-benzoyl-5'-O-[bis(4-Methoxyphenyl)phenylMethyl]-2'-deoxy-2'-fluoro-
• Synonyms: Adenosine, N-benzoyl-5'-O-[bis(4-Methoxyphenyl)phenylMethyl]-2'-deoxy-2'-fluoro-;N6-benzoyl-2'-deoxy-2'-fluoro-5'-O-(4,4'-dimethoxytrityl)adenosine;N-Benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoroadenosine;5'-O-DMT-N6-BENZOYL-2'-FLUORO-2'-DEOXYADENOSINE
• CAS NO: 136834-21-4
• Molecular Formula: C₃₈H₃₄FN₅O₆
• Molecular Weight: 675.7048632
• Mol File: 136834-21-4.mol
• Article Data: 15

Chemical Properties

• Appearance: /
• Density: 1.35±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 7.87±0.43(Predicted)
• CAS DataBase Reference: Adenosine, N-benzoyl-5'-O-[bis(4-Methoxyphenyl)phenylMethyl]-2'-deoxy-2'-fluoro-(CAS DataBase Reference)
• NIST Chemistry Reference: Adenosine, N-benzoyl-5'-O-[bis(4-Methoxyphenyl)phenylMethyl]-2'-deoxy-2'-fluoro-(136834-21-4)
• EPA Substance Registry System: Adenosine, N-benzoyl-5'-O-[bis(4-Methoxyphenyl)phenylMethyl]-2'-deoxy-2'-fluoro-(136834-21-4)

Safety Data

• Hazardous Substances Data: 136834-21-4(Hazardous Substances Data)

Usage

Description

Adenosine, N-benzoyl-5'-O-[bis(4-Methoxyphenyl)phenylMethyl]-2'-deoxy-2'-fluorois a complex organic compound with a unique molecular structure. It is a nucleoside building block derived from adenosine, a fundamental component of DNA and RNA. Adenosine, N-benzoyl-5'-O-[bis(4-Methoxyphenyl)phenylMethyl]-2'-deoxy-2'-fluorohas been modified with a benzoyl group, a bis(4-methoxyphenyl)phenylmethyl group, and a fluorine atom at the 2' position, which distinguishes it from the natural adenosine molecule. These modifications may enhance its properties and potential applications in various fields.

Uses

Used in Pharmaceutical Industry:
Adenosine, N-benzoyl-5'-O-[bis(4-Methoxyphenyl)phenylMethyl]-2'-deoxy-2'-fluorois used as a nucleoside building block for the preparation of 3'',4''-oxetane nucleosides. The application reason is its potential anti-viral properties, particularly towards Hepatitis C. The unique molecular structure of this compound may provide a new approach to developing effective treatments for this viral infection.
In addition to its use in the pharmaceutical industry, this compound may also have potential applications in other fields, such as:
1. Chemical Research:
As a complex organic molecule, Adenosine, N-benzoyl-5'-O-[bis(4-Methoxyphenyl)phenylMethyl]-2'-deoxy-2'-fluorocould be used in chemical research to study the effects of its unique structure on various chemical reactions and interactions with other molecules.
2. Material Science:
The unique properties of this compound, such as its modified adenosine structure and the presence of fluorine, may make it a candidate for the development of new materials with specific characteristics, such as improved stability or reactivity.
3. Diagnostics:
The modified adenosine structure could potentially be utilized in the development of diagnostic tools or tests, particularly in the field of molecular biology, where the detection and analysis of specific nucleosides and nucleotides are crucial.

Upstream product

• 136834-20-3 N-(9-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide 
• 98-88-4 benzoyl chloride 
• 20187-82-0 2'-fluorodeoxyadenosine 
• 136834-19-0 N⁶-benzoyl-9-<2-O-(trifluoromethylsulfonyl)-3,5-di-O-tetrahydropyran-2-yl-β-D-arabinofuranosyl>adenine 
• 146954-64-5 N⁶-benzoyl-2'-deoxy-2'-fluoro-3',5'-di-O-tetrahydropyran-2-yladenosine 
• 136834-18-9 N⁶-benzoyl-9-(3,5-di-O-tetrahydropyran-2-yl-β-D-arabinofuranosyl)adenine 
• 79896-97-2 N6-benzoyl-9-β-D-arabinofuranosyladenine 
• 40615-36-9 4,4'-dimethoxytrityl chloride 

Downstream Products

• 136834-22-5 N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenyl-methoxy]methyl]-4-[2-cyanoethoxy-(diisopropylamino)phosphanyl]oxy-3-fluoro-tetrahydrofuran-2-yl]purin-6-yl]benzamide 
• 204633-61-4 Methanesulfonic acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-fluoro-tetrahydro-furan-3-yl ester 
• 20187-82-0 2'-fluorodeoxyadenosine 
• 110143-10-7 iodenosine 
• 204633-62-5 9-{(2R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-fluoro-2,5-dihydro-furan-2-yl}-9H-purin-6-ylamine 
• 204633-63-6 (2R,3R,4R,5R)-5-(6-Amino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-fluoro-tetrahydro-furan-3-ol 

Relevant articles and documents

Cyclic dinucleotide analogues, pharmaceutical composition of analogues and applications of analogues and pharmaceutical composition

The invention discloses cyclic dinucleotide analogues, a pharmaceutical composition of the analogues and applications of the analogues and the pharmaceutical composition. The cyclic dinucleotide analogs (I), an isomer, prodrug, stable isotope derivative or pharmaceutically acceptable salt of the analogs have a structure shown in the specification. The cyclic dinucleotide analogs provided by the invention can be used as regulators of stimulator of interferon genes (STIG) and related signaling pathways, and can effectively treat and/or alleviate multiple types of diseases, including but not limited to malignant tumors, inflammation, autoimmune diseases and infectious diseases; and in addition, the STING regulators can also be used as vaccine adjuvants.

Cyclopentane-Based Modulators of STING (Stimulator of Interferon Genes)

Compounds of the general formula (I): or a pharmaceutically acceptable salt thereof, processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.

CYCLIC DINUCLEOTIDES AS STING AGONISTS

Disclosed are compounds, compositions and methods for treating of diseases, syndromes, or disorders that are affected by the modulation of STING. Such compounds are represented by Formula (I) as follows: wherein R, R1B, R1C, R2B