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Adenosine, N-benzoyl-5'-O-[bis(4-Methoxyphenyl)phenylMethyl]-2'-deoxy-2'-fluorois a complex organic compound with a unique molecular structure. It is a nucleoside building block derived from adenosine, a fundamental component of DNA and RNA. Adenosine, N-benzoyl-5'-O-[bis(4-Methoxyphenyl)phenylMethyl]-2'-deoxy-2'-fluorohas been modified with a benzoyl group, a bis(4-methoxyphenyl)phenylmethyl group, and a fluorine atom at the 2' position, which distinguishes it from the natural adenosine molecule. These modifications may enhance its properties and potential applications in various fields.

136834-21-4

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  • Adenosine, N-benzoyl-5'-O-[bis(4-Methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-

    Cas No: 136834-21-4

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136834-21-4 Usage

Uses

Used in Pharmaceutical Industry:
Adenosine, N-benzoyl-5'-O-[bis(4-Methoxyphenyl)phenylMethyl]-2'-deoxy-2'-fluorois used as a nucleoside building block for the preparation of 3'',4''-oxetane nucleosides. The application reason is its potential anti-viral properties, particularly towards Hepatitis C. The unique molecular structure of Adenosine, N-benzoyl-5'-O-[bis(4-Methoxyphenyl)phenylMethyl]-2'-deoxy-2'-fluoro- may provide a new approach to developing effective treatments for this viral infection.
In addition to its use in the pharmaceutical industry, Adenosine, N-benzoyl-5'-O-[bis(4-Methoxyphenyl)phenylMethyl]-2'-deoxy-2'-fluoro- may also have potential applications in other fields, such as:
1. Chemical Research:
As a complex organic molecule, Adenosine, N-benzoyl-5'-O-[bis(4-Methoxyphenyl)phenylMethyl]-2'-deoxy-2'-fluorocould be used in chemical research to study the effects of its unique structure on various chemical reactions and interactions with other molecules.
2. Material Science:
The unique properties of Adenosine, N-benzoyl-5'-O-[bis(4-Methoxyphenyl)phenylMethyl]-2'-deoxy-2'-fluoro-, such as its modified adenosine structure and the presence of fluorine, may make it a candidate for the development of new materials with specific characteristics, such as improved stability or reactivity.
3. Diagnostics:
The modified adenosine structure could potentially be utilized in the development of diagnostic tools or tests, particularly in the field of molecular biology, where the detection and analysis of specific nucleosides and nucleotides are crucial.

Check Digit Verification of cas no

The CAS Registry Mumber 136834-21-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,6,8,3 and 4 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 136834-21:
(8*1)+(7*3)+(6*6)+(5*8)+(4*3)+(3*4)+(2*2)+(1*1)=134
134 % 10 = 4
So 136834-21-4 is a valid CAS Registry Number.

136834-21-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name N6-benzoyl-2'-deoxy-2'-fluoro-5'-O-(4,4'-dimethoxytrityl)adenosine

1.2 Other means of identification

Product number -
Other names DMT-2'-F-Bz-dA

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:136834-21-4 SDS

136834-21-4Relevant articles and documents

SALTS OF COMPOUNDS AND CRYSTALS THEREOF

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Paragraph 0054, (2020/03/05)

The present invention provides crystals of (1R,3R,15E,28R,29R,30R,31R,34R,36R,39S,41R)-29,41-Difluoro-34,39-bis(sulfanyl)-2,33,35,38,40,42-hexaoxa-4,6,9,11,13,18,20,22,25,27-decaaza-34λ5,39λ5-diphosphaoctacyclo[28.6.4.13,36/sup

Cyclic dinucleotide analogues, pharmaceutical composition of analogues and applications of analogues and pharmaceutical composition

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Paragraph 0432; 0433; 0435, (2020/04/17)

The invention discloses cyclic dinucleotide analogues, a pharmaceutical composition of the analogues and applications of the analogues and the pharmaceutical composition. The cyclic dinucleotide analogs (I), an isomer, prodrug, stable isotope derivative or pharmaceutically acceptable salt of the analogs have a structure shown in the specification. The cyclic dinucleotide analogs provided by the invention can be used as regulators of stimulator of interferon genes (STIG) and related signaling pathways, and can effectively treat and/or alleviate multiple types of diseases, including but not limited to malignant tumors, inflammation, autoimmune diseases and infectious diseases; and in addition, the STING regulators can also be used as vaccine adjuvants.

CYCLIC DI-NUCLEOTIDES AS STIMULATOR OF INTERFERON GENES MODULATORS

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Paragraph 00832; 00833; 00834, (2019/03/17)

The present disclosure relates to a compound of formulae (I) or (II), or a pharmaceutically acceptable salt, a solvate, a hydrate thereof, a pharmaceutical composition comprising a compound of formulae (I) or (II), and use thereof, wherein various Markush

Cyclopentane-Based Modulators of STING (Stimulator of Interferon Genes)

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, (2019/09/30)

Compounds of the general formula (I): or a pharmaceutically acceptable salt thereof, processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.

CYCLIC DI-NUCLEOTIDES COMPOUNDS FOR THE TREATMENT OF CANCER

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Page/Page column 61; 62, (2018/09/12)

Provided herein are compounds useful for the treatment of cancer.

CYCLIC DINUCLEOTIDES AS AGONISTS OF STIMULATOR OF INTERFERON GENE DEPENDENT SIGNALLING

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Paragraph 0290; 0291, (2018/09/26)

Disclosed herein are new cyclic dinucleotide compounds and compositions and their application as pharmaceuticals for the treatment of disease. Methods of modulation of immune response to disease, and induce Stimulator of Interferon Genes (STING) dependent type I interferon production and co-regulated genes in a human or animal subject are also provided for the treatment diseases such as cancer, particularly metastatic solid tumors and lymphomas, inflammation, allergic and autoimmune disease, infectious disease, and for use as anti-viral agents and vaccine adjuvants.

CYCLIC DINUCLEOTIDES AS STING AGONISTS

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Page/Page column 109; 138; 174; 176, (2018/08/20)

Disclosed are compounds, compositions and methods for treating of diseases, syndromes, or disorders that are affected by the modulation of STING. Such compounds are represented by Formula (I) as follows: wherein R, R1B, R1C, R2B

Synthesis and anti-HCV activity of 3′,4′-oxetane nucleosides

Chang, Wonsuk,Du, Jinfa,Rachakonda, Suguna,Ross, Bruce S.,Convers-Reignier, Serge,Yau, Wei T.,Pons, Jean-Francois,Murakami, Eisuke,Bao, Haiying,Steuer, Holly Micolochick,Furman, Phillip A.,Otto, Michael J.,Sofia, Michael J.

scheme or table, p. 4539 - 4543 (2010/11/03)

Hepatitis C virus afflicts approximately 180 million people worldwide and currently there are no direct acting antiviral agents available to treat this disease. Our first generation nucleoside HCV inhibitor, RG7128 has already established proof-of-concept

Antisense modulation of polo-like kinase expression

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Page/Page column 18, (2008/06/13)

Antisense compounds, compositions and methods are provided for modulating the expression of polo-like kinase. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding polo-like kinase. Methods of using these compounds for modulation of polo-like kinase expression and for treatment of diseases associated with expression of polo-like kinase are provided.

Antisense modulation of perilipin expression

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Page/Page column 18, (2008/06/13)

Antisense compounds, compositions and methods are provided for modulating the expression of perilipin. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding perilipin. Methods of using these compounds for modulation of perilipin expression and for treatment of diseases associated with expression of perilipin are provided.

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