136834-20-3

Basic information

• Product Name: N6-Benzoyl-2'-Fluoro-2'-deoxyadenosine
• Synonyms: N6-Benzoyl-2'-Fluoro-2'-deoxyadenosine;Bz-2'-F-dA;Adenosine, N-benzoyl-2'-deoxy-2'-fluoro-;N-Benzoyl-2'-deoxy-2'-fluoroadenosine;N6-Benzoyl-2'-deoxy-2'-fluoroadenosine
• CAS NO: 136834-20-3
• Molecular Formula: C₁₇H₁₆FN₅O₄
• Molecular Weight: 373.3384432
• Mol File: 136834-20-3.mol
• Article Data: 19

Chemical Properties

• Appearance: /
• Density: 1.67±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 7.87±0.43(Predicted)
• CAS DataBase Reference: N6-Benzoyl-2'-Fluoro-2'-deoxyadenosine(CAS DataBase Reference)
• NIST Chemistry Reference: N6-Benzoyl-2'-Fluoro-2'-deoxyadenosine(136834-20-3)
• EPA Substance Registry System: N6-Benzoyl-2'-Fluoro-2'-deoxyadenosine(136834-20-3)

Safety Data

• Hazardous Substances Data: 136834-20-3(Hazardous Substances Data)

Usage

General Description

N6-Benzoyl-2'-Fluoro-2'-deoxyadenosine is a chemical compound that belongs to the nucleoside analog family. It is derived from adenosine, one of the building blocks of DNA and RNA. N6-Benzoyl-2'-Fluoro-2'-deoxyadenosine has a benzoyl group attached to the N6 position and a fluoro group attached to the 2' position of the sugar moiety of adenosine. These modifications in the structure of adenosine alter its properties and can potentially impact its biological activity. N6-Benzoyl-2'-Fluoro-2'-deoxyadenosine may find applications in various fields, including medicinal chemistry research and drug discovery, where it can be used as a tool compound to investigate the effects of specific modifications on nucleoside structures.

Upstream product

• 98-88-4 benzoyl chloride 
• 20187-82-0 2'-fluorodeoxyadenosine 
• 58-61-7 adenosine 
• 5536-17-4 arabinosyl adenine 
• 136834-19-0 N⁶-benzoyl-9-<2-O-(trifluoromethylsulfonyl)-3,5-di-O-tetrahydropyran-2-yl-β-D-arabinofuranosyl>adenine 
• 136834-18-9 N⁶-benzoyl-9-(3,5-di-O-tetrahydropyran-2-yl-β-D-arabinofuranosyl)adenine 
• 79896-97-2 N6-benzoyl-9-β-D-arabinofuranosyladenine 
• 146954-64-5 N⁶-benzoyl-2'-deoxy-2'-fluoro-3',5'-di-O-tetrahydropyran-2-yladenosine 

Downstream Products

• 1172119-72-0 C₂₇H₃₄FN₇O₅ 
• 1417910-10-1 N₆-benzoyl-2-deoxy-2-fluoro-5-O-levulinyladenosine 
• 146954-64-5 N⁶-benzoyl-2'-deoxy-2'-fluoro-3',5'-di-O-tetrahydropyran-2-yladenosine 
• 136834-22-5 N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenyl-methoxy]methyl]-4-[2-cyanoethoxy-(diisopropylamino)phosphanyl]oxy-3-fluoro-tetrahydrofuran-2-yl]purin-6-yl]benzamide 
• 204633-63-6 (2R,3R,4R,5R)-5-(6-Amino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-fluoro-tetrahydro-furan-3-ol 
• 204633-61-4 Methanesulfonic acid (2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-fluoro-tetrahydro-furan-3-yl ester 
• 204633-62-5 9-{(2R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-fluoro-2,5-dihydro-furan-2-yl}-9H-purin-6-ylamine 
• 110143-10-7 iodenosine 
• 20187-82-0 2'-fluorodeoxyadenosine 
• 136834-21-4 N-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)3-fluoro-4-hydroxytetrahydrofuran-2-yl)9H-purin-6yl)benzamide triethylammonium salt 

Relevant articles and documents

CYCLIC DINUCLEOTIDE COMPOUND AND USES THEREOF

Provided are a compound of formula (I), an optical isomer thereof, a pharmaceutically acceptable salt thereof, uses of said compound acting as a STING agonist.

CYCLIC DINUCLEOTIDES AS STING AGONISTS

Disclosed are compounds, compositions and methods for treating of diseases, syndromes, or disorders that are affected by the modulation of STING. Such compounds are represented by Formula (I) as follows: wherein R, R1B, R1C, R2B

INHIBITORS OF S-ADENOSYL-L-METHIONINE DECARBOXYLASE

Novel mechanism-based inhibitors of S-adenosyl-L-methionine decarboxylase are provided. These compounds of formula (1) inhibit the life cycle of trypanosomes, and are useful to treat subjects infected with African trypanosomes. The invention includes pharmaceutical compositions and methods of using the compounds of formula (1).