136845-52-8Relevant academic research and scientific papers
SYNTHESIS OF TOCOTRIENOLS FROM O-CRESOL DERIVATIVES
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, (2019/04/11)
The present invention provides an environmentally benign, facile process for preparation of Tocotrienols from commercially available derivatives of o-Cresol.
A short and convenient chemical route to optically pure 2-methyl chromanmethanols. Total asymmetric synthesis of β-, γ-, and δ-tocotrienols
Couladouros, Elias A.,Moutsos, Vassilios I.,Lampropoulou, Maria,Little, James L.,Hyatt, John A.
, p. 6735 - 6741 (2008/02/11)
(Chemical Equation Presented) With use of inexpensive commercially available raw materials, chromanmethanol precursors to the natural β-, γ-, and δ-tocotrienols have been prepared in high yield. Enzymatic resolution afforded chiral chromanmethanols in high enantiomeric excess. Subsequent attachment of the farnesyl side chain was high yielding, thus allowing the preparation of asymmetric β-, γ-, and δ-tocotrienols in one final step wherein simultaneous deprotection of the phenol and removal of the sulfone group occurs. This chemistry provides the first synthesis of natural-series β-tocotrienol.
Constituents of the seeds of Garcinia kola: Two new antioxidants, garcinoic acid and garcinal
Terashima, Kenji,Shimamura, Tomoyuki,Tanabayashi, Miho,Aqil, Mohammad,Akinniyi, John A.,Niwa, Masatake
, p. 1559 - 1566 (2007/10/03)
Two new chromanols, named garcinoic acid and garcinal, were isolated together with a known chromanol, δ-tocotrienol and three known biflavonoids, garcinianin, GB-1 and GB-2, from the seeds of Garcinia kola Heckel (Guttiferae) collected in Nigeria and their structures were characterized on the basis of the spectroscopic and chemical evidence. Garcinoic acid, garcinal and δ-tocotrienol showed about 1.5 times stronger antioxidation activity than that of dl-α-tocopherol.
