71528-84-2Relevant academic research and scientific papers
A short and convenient chemical route to optically pure 2-methyl chromanmethanols. Total asymmetric synthesis of β-, γ-, and δ-tocotrienols
Couladouros, Elias A.,Moutsos, Vassilios I.,Lampropoulou, Maria,Little, James L.,Hyatt, John A.
, p. 6735 - 6741 (2008/02/11)
(Chemical Equation Presented) With use of inexpensive commercially available raw materials, chromanmethanol precursors to the natural β-, γ-, and δ-tocotrienols have been prepared in high yield. Enzymatic resolution afforded chiral chromanmethanols in high enantiomeric excess. Subsequent attachment of the farnesyl side chain was high yielding, thus allowing the preparation of asymmetric β-, γ-, and δ-tocotrienols in one final step wherein simultaneous deprotection of the phenol and removal of the sulfone group occurs. This chemistry provides the first synthesis of natural-series β-tocotrienol.
HYDROQUINONE DERIVATIVES
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, (2008/06/13)
A hydroquinone derivative useful as an intraocular pressure lowering, anti-hypertensive and radical scavenging agent represented by the following formula wherein B1 and B2 in formula (I) are the same or different and at any position on the benzene ring (when W is nitrogen, however, at any other position on the benzene ring) and each denotes a substituent selected from the group consisting of hydrogen, halogen, hydroxyl, lower alkoxyl and carboxyl, and the substituent CH3 is at position 2 or 3, and W are the same or different and each denotes a nitrogen or carbon atom. R1, R2, R3 and R4 in formula (II) are the same or different and each denotes a substituent selected from the group consisting of hydrogen, lower alkyl and lower alkoxyl, and B1 and B2 are as hereinbefore defined, or a pharmacologically acceptable salt thereof.
