13687-98-4Relevant academic research and scientific papers
CHEMISTRY OF ENOL ETHERS. SYNTHESIS OF UNSATURATED ALDEHYDO ACIDS AND THEIR DERIVATIVES - SYNTHONS FOR RETINOIDS
Makin, S. M.,Dobretsova, E. K.,Shavrygina, O. A.,Arshava, B. M.
, p. 445 - 448 (2007/10/02)
The reaction of 2-ethoxy-6-ethoxycarbonyl-5,6-dihydro-2H-pyrans with acidic reagents led to the synthesis of the esters of unsubstituted and methyl-substituted 2-hydroxy-6-oxo-4-hexenoic acids and 6-oxo-2E,4E-hexadienoic acids, which can be used in the synthesis of retinoids and their analogs.The initial 2-ethoxy-6-ethoxycarbonyl-5,6-dihydro-2H-pyrans were obtained by the diene condensation of ethyl glyoxylate with 1-ethoxy-1,3-dienes.
