1369072-00-3Relevant academic research and scientific papers
Syntheses and electrochemical properties of novel aminopyrimidinone derivatives as a new class of abasic-site binders
Chiba, Junya,Doi, Yasuhiro,Inouye, Masahiko
, p. 177 - 183 (2013)
We describe syntheses and electrochemical properties of a new class of aminopyrimidinone derivatives: 2-amino-4-(3',4'-dimethoxyphenyl)-6-pyrimidinone, 2-amino-4-(3',4'-dihydroxyphenyl)-6-pyrimidinone, 2,4-diamino-5-(3',4'- dimethoxyphenyl)-6-pyrimidinone, 2,4-diamino-5-(3',4'-dihydroxyphenyl)-6- pyrimidinone, and 4-amino-5-(3',4'-dihydroxyphenyl)-2,6-pyrimidinione, three of which possess a catechol unit as an oxidation-active moiety for developing electrochemically detectable abasic-site binders. These compounds were synthesized via a pyrimidine-ring forming reaction with guanidine. Cyclic voltammetry measurements revealed that the catechol-bearing derivatives showed oxidation potentials lower than that of DNA, indicating that they satisfied the requirements for the purpose. Graphical Abstract: [Figure not available: see fulltext.]
Identification of novel isocytosine derivatives as xanthine oxidase inhibitors from a set of virtual screening hits
B-Rao, Chandrika,Kulkarni-Almeida, Asha,Katkar, Kamlesh V.,Khanna, Smriti,Ghosh, Usha,Keche, Ashish,Shah, Pranay,Srivastava, Ankita,Korde, Vaidehi,Nemmani, Kumar V.S.,Deshmukh, Nitin J.,Dixit, Amol,Brahma, Manoja K.,Bahirat, Umakant,Doshi, Lalit,Sharma, Rajiv,Sivaramakrishnan
experimental part, p. 2930 - 2939 (2012/06/29)
In recent years, xanthine oxidase has emerged as an important target not only for gout but also for cardiovascular and metabolic disorders involving hyperuricemia. Contrary to popular belief, recent clinical trials with uricosurics have demonstrated that
