1369353-14-9

Usage

Chemical class

Amine compound

Basic structure

Organic molecule containing a basic nitrogen atom

Derivative of

Azepane

Methylamine group attachment

Fourth carbon atom

"1-Boc" prefix

Indicates the presence of a tert-butoxycarbonyl (Boc) protecting group

Boc group function

Blocks the reactivity of amines and protects them during synthetic reactions

Applications

a. Production of pharmaceutical drugs
b. Building block for the synthesis of other complex molecules

Usage

Often used in organic synthesis and pharmaceutical research

Upstream product

• 1259056-34-2 tert-butyl 4-cyanoazepane-1-carboxylate 
• 188975-88-4 tert-butyl 4-oxoazepane-1-carboxylate 
• 1065608-51-6 tert-butyl 4-(hydroxymethyl)azepane-1-carboxylate 
• 912444-90-7 1-(tertbutyl) 4-ethyl 2,3,6,7-tetrahydro-1H-azepine-1,4-dicarboxylate 

Relevant academic research and scientific papers

INHIBITORS OF ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE 1 (ENPP1) AND METHODS OF USE THEREOF

Compounds and methods for their preparation and use as therapeutic or prophylactic agents, for example for treatment of cancer, bacterial or viral diseases by targeting Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1).

METALLO-BETA-LACTAMASE INHIBITORS AND METHODS OF USE THEREOF

The present invention relates to metallo-β-lactamase inhibitor compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein Z, RA, X1, X2 and R1 are as defined herein. The present invention also relates to compositions which comprise a metallo-β-lactamase inhibitor compound of the invention or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, optionally in combination with a beta lactam antibiotic and/or a beta-lactamase inhibitor. The invention further relates to methods for treating a bacterial infection comprising administering to a patient a therapeutically effective amount of a compound of the invention, in combination with a therapeutically effective amount of one or more β-lactam antibiotics and optionally in combination with one or more beta-lactamase inhibitor compounds. The compounds of the invention are useful in the methods described herein for overcoming antibiotic resistance.

PYRAZOLOPYRIDINE PYRAZOLOPYRIMIDINE AND RELATED COMPOUNDS

In one aspect this invention relates generally to compounds of Formula: and sub-formulas thereof, or a tautomer of each thereof, a pharmaceutically acceptable salt of each thereof, or a pharmaceutically acceptable solvate of each of the foregoing, where X1, L1, L3, and R3 are described herein.