1369430-38-5

Basic information

• Product Name: ethyl 5-(4-benzamidophenyl)isoxazole-3-carboxylate
• Synonyms: ethyl 5-(4-benzamidophenyl)isoxazole-3-carboxylate
• CAS NO: 1369430-38-5
• Molecular Weight: 336.347
• Mol File: 1369430-38-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl 5-(4-benzamidophenyl)isoxazole-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 5-(4-benzamidophenyl)isoxazole-3-carboxylate(1369430-38-5)
• EPA Substance Registry System: ethyl 5-(4-benzamidophenyl)isoxazole-3-carboxylate(1369430-38-5)

Safety Data

• Hazardous Substances Data: 1369430-38-5(Hazardous Substances Data)

Upstream product

• 100-19-6 (4-nitrophenyl)ethanone 
• 908802-68-6 ethyl 5-(4-amino-phenyl)isoxazole-3-carboxylate 
• 98-88-4 benzoyl chloride 
• 159670-70-9 ethyl 5-(4-nitrophenyl)isoxazole-3-carboxylate 
• 54808-56-9 4-(4-nitrophenyl)-2,4-dione-butyric acid ethyl ester 

Relevant articles and documents

Design and synthesis of phenylisoxazole derivatives as novel human acrosin inhibitors

Human acrosin is an attractive target for the discovery of novel male contraceptives. Isoxazole derivative ISO-1, a small-molecule weak human acrosin inhibitor, was used as the starting point for lead optimization. After two rounds of structure-based inhibitor design, a highly potent inhibitor B6 (IC50 = 1.44 μM) was successfully identified, which showed good selectivity over trypsin and represents one of the most active human acrosin inhibitors up to date.