1369572-77-9

Basic information

• Product Name: C₁₉H₁₆O₆
• Synonyms: C₁₉H₁₆O₆
• CAS NO: 1369572-77-9
• Molecular Weight: 340.332
• Mol File: 1369572-77-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₁₉H₁₆O₆(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₉H₁₆O₆(1369572-77-9)
• EPA Substance Registry System: C₁₉H₁₆O₆(1369572-77-9)

Safety Data

• Hazardous Substances Data: 1369572-77-9(Hazardous Substances Data)

Upstream product

• 92-61-5 7-hydroxy-6-methoxy-2H-1-benzopyran-2-one 
• 51061-83-7 2,4-dihydroxy-5-methoxybenzaldehyde 

Relevant articles and documents

Synthesis and biological evaluation of scopoletin derivatives

A series of new scopoletin derivatives were designed and synthesized. Their anti-proliferative effect was initially evaluated against various human cancer cell lines. Among the tested compounds, A1, A2, and D6 showed significant anti-proliferative activities. Angiogenesis was detected by endothelial cell migration assay and tube formation study. The results showed that A1, A2, and D6 inhibited the vascular endothelial growth factor (VEGF)-stimulated proliferation, migration, and tube formation of human umbilical vein endothelial cells in vitro. Moreover, they inhibited the vessel growth in the chorioallantoic membrane in vivo. This inhibition was correlated with a significant decrease in the VEGF-triggered phosphorylated forms of ERK1/2 and Akt. In summary, these findings strongly suggested that these scopoletin derivatives might be structurally novel angiogenesis inhibitors.