1369810-86-5

Upstream product

• 1369810-85-4 tert-butyl (3R,4R)-3,4-bis(benzyloxy)-5-hydroxy-2-methylenepentylcarbamate 
• 124-63-0 methanesulfonyl chloride 

Downstream Products

• 177420-29-0 (3R,4R)-tert-butyl 3,4-bis(benzyloxy)-5-methylenepiperidine-1-carboxylate 
• 1369810-92-3 (3R,4S,5R)-tert-butyl 4,5-bis(benzyloxy)-3-hydroxy-3-(hydroxymethyl)piperidine-1-carboxylate 
• 1369810-93-4 (3S,4S,5R)-tert-butyl 4,5-bis(benzyloxy)-3-hydroxy-3-(hydroxymethyl)piperidine-1-carboxylate 
• 169105-89-9 isofagomine 
• 275363-98-9 (3R,4R,5S)-3,4-dihydroxy-5-hydroxymethylpiperidine 

Relevant academic research and scientific papers

Aza-Claisen rearrangement of 2-C-hydroxymethyl glycals as a versatile strategy towards synthesis of isofagomine and related biologically important azasugars

Synthesis of isofagomine has been achieved by implementation of aza-Claisen rearrangement of 2-C-hydroxymethyl glycals as a key step. The above rearrangement has also been utilized in the synthesis of biologically important polyhydroxylated piperidine frameworks such as isogalactofagomine, ent-isogalactofagomine and their analogues and some other azasugars as glycosidase inhibitors. The Royal Society of Chemistry 2012.