1370244-29-3

Basic information

• Product Name: 2-[3-chloro-4-(1-oxopropyl)phenoxymethyl]-4-(naphthalen-2-yl)thiazole
• Synonyms: 2-[3-chloro-4-(1-oxopropyl)phenoxymethyl]-4-(naphthalen-2-yl)thiazole
• CAS NO: 1370244-29-3
• Molecular Weight: 407.92
• Mol File: 1370244-29-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-[3-chloro-4-(1-oxopropyl)phenoxymethyl]-4-(naphthalen-2-yl)thiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[3-chloro-4-(1-oxopropyl)phenoxymethyl]-4-(naphthalen-2-yl)thiazole(1370244-29-3)
• EPA Substance Registry System: 2-[3-chloro-4-(1-oxopropyl)phenoxymethyl]-4-(naphthalen-2-yl)thiazole(1370244-29-3)

Safety Data

• Hazardous Substances Data: 1370244-29-3(Hazardous Substances Data)

Upstream product

• 93-08-3 methyl 2-naphthyl ketone 
• 35370-95-7 2-(3-chlorophenoxy) ethanethioamide 
• 114476-84-5 2-(3-chlorophenoxy)acetyl chloride 
• 1370244-41-9 2-[3-chloro-4-(1-oxo-propyl)phenoxy]ethanethioamide 
• 613-54-7 2-Bromo-2'-acetonaphthone 

Downstream Products

• 1370243-93-8 2-[3-chloro-4-(2-methylene-1-oxopropyl)phenoxymethyl]-4-(naphthalen-2-yl)thiazole 

Relevant articles and documents

The synthesis of ethacrynic acid thiazole derivatives as glutathione S-transferase pi inhibitors

Glutathione S-transferase pi (GSTpi) is a phase II enzyme which protects cells from death and detoxifies chemotherapeutic agents in cancer cells. Ethacrynic acid (EA) is a weak GSTpi inhibitor. Structure modifications were done to improve the ability of EA to inhibit GSTpi activity. Eighteen EA thiazole derivatives were designed and synthesized. Compounds 9a, 9b and 9c with a replacement of carboxyl group of EA by a heterocyclic thiazole exhibited improvement over EA to inhibit GSTpi activity.