35370-95-7

Basic information

• Product Name: 2-(3-CHLOROPHENOXY)ETHANETHIOAMIDE
• Synonyms: BUTTPARK 94\57-10;2-(3-CHLOROPHENOXY)THIOACETAMIDE;2-(3-CHLOROPHENOXY)ETHANETHIOAMIDE;2-(3-Chlorophenoxy)ethanethioamide, 95+%;2-(3-CHLOROPHENOXY)THIOACETAMIDE 99%
• CAS NO: 35370-95-7
• Molecular Formula: C₈H₈ClNOS
• Molecular Weight: 201.67
• Mol File: 35370-95-7.mol
• Article Data: 1

Chemical Properties

• Melting Point: 122-124
• Boiling Point: 338.6°Cat760mmHg
• Flash Point: 158.6°C
• Appearance: /
• Density: 1.339g/cm³
• Vapor Pressure: 9.72E-05mmHg at 25°C
• Refractive Index: 1.625
• CAS DataBase Reference: 2-(3-CHLOROPHENOXY)ETHANETHIOAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-CHLOROPHENOXY)ETHANETHIOAMIDE(35370-95-7)
• EPA Substance Registry System: 2-(3-CHLOROPHENOXY)ETHANETHIOAMIDE(35370-95-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-43-36
• Safety Statements: 26-36/37/39-36/37
• Hazardous Substances Data: 35370-95-7(Hazardous Substances Data)

Usage

Thioamide derivative

Contains both an ether and a thiol functional group

Uses

Building block in organic synthesis, pharmaceutical research, production of agrochemicals and biocides, potential applications in medicinal chemistry and drug development

Chemical properties and reactivity

Valuable component in various industrial and scientific processes

InChI:InChI=1/C8H8ClNOS/c9-6-2-1-3-7(4-6)11-5-8(10)12/h1-4H,5H2,(H2,10,12)

Upstream product

• 43111-32-6 (3-chloro-phenoxy)-acetonitrile 
• 108-43-0 3-monochlorophenol 
• 114476-84-5 2-(3-chlorophenoxy)acetyl chloride 
• 588-32-9 3-chlorophenoxyacetic acid 
• 35368-69-5 2-(3-chlorophenoxy)acetamide 
• 74411-14-6 methyl 2-(3-chlorophenoxy)acetate 

Downstream Products

• 1370244-05-5 2-[3-chloro-4-(1-oxopropyl)phenoxymethyl]-4-phenylthiazole 
• 1370244-21-5 2-[3-chloro-4-(1-oxobutyl)phenoxymethyl]-4-(4-nitrophenyl)thiazole 
• 1370244-23-7 2-[3-chloro-4-(1-oxobutyl)phenoxymethyl]-4-(naphthalen-2-yl)thiazole 
• 1370244-25-9 2-[3-chloro-4-(1-oxobutyl)phenoxymethyl]-4-(4-trifluoromethylphenyl)thiazole 
• 1370244-27-1 2-[3-chloro-4-(1-oxopropyl)phenoxymethyl]-4-(4-nitrophenyl)thiazole 
• 1370244-29-3 2-[3-chloro-4-(1-oxopropyl)phenoxymethyl]-4-(naphthalen-2-yl)thiazole 
• 1370244-31-7 2-[3-chloro-4-(1-oxopropyl)phenoxymethyl]-4-(4-trifluoromethylphenyl)thiazole 
• 1370243-70-1 2-[3-chloro-4-(2-methylene-1-oxopropyl) phenoxymethyl]-4-phenylthiazole 
• 1370243-85-8 2-[3-chloro-4-(2-methylene-1-oxobutyl)phenoxymethyl]-4-(4-nitrophenyl)thiazole 
• 1370243-87-0 2-[3-chloro-4-(2-methylene-1-oxobutyl) phenoxymethyl]-4-(naphthalen-2-yl)thiazole 
• 1370243-89-2 2-[3-chloro-4-(2-methylene-1-oxobutyl)phenoxymethyl]-4-(4-trifluoromethylphenyl)thiazole 
• 1370243-91-6 2-(3-chloro-4-(2-methylene-1-oxopropyl)phenoxymethyl)-4-(4-nitrophenyl)thiazole 
• 1370243-93-8 2-[3-chloro-4-(2-methylene-1-oxopropyl)phenoxymethyl]-4-(naphthalen-2-yl)thiazole 
• 1370243-95-0 2-[3-chloro-4-(2-methylene-1-oxopropyl)phenoxymethyl]-4-(4-trifluoromethylphenyl)thiazole 

Relevant articles and documents

The synthesis of ethacrynic acid thiazole derivatives as glutathione S-transferase pi inhibitors

Glutathione S-transferase pi (GSTpi) is a phase II enzyme which protects cells from death and detoxifies chemotherapeutic agents in cancer cells. Ethacrynic acid (EA) is a weak GSTpi inhibitor. Structure modifications were done to improve the ability of EA to inhibit GSTpi activity. Eighteen EA thiazole derivatives were designed and synthesized. Compounds 9a, 9b and 9c with a replacement of carboxyl group of EA by a heterocyclic thiazole exhibited improvement over EA to inhibit GSTpi activity.