1370409-55-4

Basic information

• Product Name: 2-(4-methoxyphenyl)-3-[4-(methylsulfanyl)phenyl]-7-nitroimidazo[2,1b][1,3] benzothiazole
• CAS NO: 1370409-55-4
• Molecular Weight: 447.538
• Mol File: 1370409-55-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(4-methoxyphenyl)-3-[4-(methylsulfanyl)phenyl]-7-nitroimidazo[2,1b][1,3] benzothiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-methoxyphenyl)-3-[4-(methylsulfanyl)phenyl]-7-nitroimidazo[2,1b][1,3] benzothiazole(1370409-55-4)
• EPA Substance Registry System: 2-(4-methoxyphenyl)-3-[4-(methylsulfanyl)phenyl]-7-nitroimidazo[2,1b][1,3] benzothiazole(1370409-55-4)

Safety Data

• Hazardous Substances Data: 1370409-55-4(Hazardous Substances Data)

Upstream product

• 150-13-0 4-amino-benzoic acid 
• 18330-64-8 4-amino-3-thiocyanatobenzoic acid 
• 100-01-6 4-nitro-aniline 
• 33420-82-5 2-(4-methoxy-phenyl)-1-(4-methylsulfanyl-phenyl)ethanone 
• 100-68-5 methyl-phenyl-thioether 
• 68310-01-0 C₇H₅N₃O₂S 
• 6285-57-0 2-amino-6-nitrobenzothiazole 
• 104-01-8 4-Methoxyphenylacetic acid 

Relevant articles and documents

Synthesis and preliminary in-vitro cytotoxic activity of novel substituted diaryl-imidazo [2,1,b]-benzothiazole derivatives

A novel series of substituted diaryl imidazo[2,1-b]benzothiazole derivatives (8a-y) were synthesized by condensation reaction between 2-amino benzothiazole derivatives (3a-g) and substituted α-bromo-1, 2-(substituted) diaryl-1-ethanones (7a-i). The structures of the synthesized compounds were established by IR, 1H NMR, 13C NMR and mass spectroscopical data. The compounds (8a-y) were evaluated for their in-vitro cytotoxic activity on murine (B16F10) and human (MCF-7) cancer cells by using MTT assay. From the in vitro studies compounds 8p, 8u and 8y were found most effective with an IC50 range of 0.56-27.50 μM in MCF-7 and 2.57-36.54 μM in B16F10 cells.