68310-01-0

Basic information

• Product Name: 2-amino-5-nitrophenyl thiocyanate
• Synonyms: 2-amino-5-nitrophenyl thiocyanate;Thiocyanic acid 2-amino-5-nitrophenyl ester
• CAS NO: 68310-01-0
• Molecular Formula: C₇H₅N₃O₂S
• Molecular Weight: 195.1985
• EINECS: 269-689-5
• Mol File: 68310-01-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 378.2°C at 760 mmHg
• Flash Point: 182.5°C
• Appearance: /
• Density: 1.5g/cm³
• Vapor Pressure: 6.38E-06mmHg at 25°C
• Refractive Index: 1.679
• CAS DataBase Reference: 2-amino-5-nitrophenyl thiocyanate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-5-nitrophenyl thiocyanate(68310-01-0)
• EPA Substance Registry System: 2-amino-5-nitrophenyl thiocyanate(68310-01-0)

Safety Data

• Hazardous Substances Data: 68310-01-0(Hazardous Substances Data)

Usage

Chemical type

Aromatic nitro compound

Functional groups

Amino group (NH2), thiocyanate group (SCN-)

Usage

Used in organic synthesis and chemical research as a reagent or building block for the preparation of various organic compounds

Antimicrobial activity

Known for its potential antimicrobial activity

Potential applications

Studied for potential applications in the pharmaceutical industry

Physical properties

Yellow crystalline solid, sparingly soluble in water and most organic solvents

Versatility

Suitable for use in a variety of chemical reactions and processes.

InChI:InChI=1/C7H5N3O2S/c8-4-13-7-3-5(10(11)12)1-2-6(7)9/h1-3H,9H2

Upstream product

• 333-20-0 potassium thioacyanate 
• 100-01-6 4-nitro-aniline 

Downstream Products

• 1240167-82-1 2,3-bis(4-methoxyphenyl)-7-nitroimidazo[2,1-b][1,3]benzothiazole 
• 1370409-54-3 2-(2,4-dichlorophenyl)-3-(4-methylphenyl)-7-nitroimidazo[2,1-b][1,3]benzothiazole 
• 1370409-55-4 2-(4-methoxyphenyl)-3-[4-(methylsulfanyl)phenyl]-7-nitroimidazo[2,1b][1,3] benzothiazole 
• 6285-57-0 2-amino-6-nitrobenzothiazole 

Relevant articles and documents

Synthesis and preliminary in-vitro cytotoxic activity of novel substituted diaryl-imidazo [2, 1, b]-benzothiazole derivatives

A novel series of substituted diaryl imidazo[2, 1-b]benzothiazole derivatives (8a-y) were synthesized by condensation reaction between 2-amino benzothiazole derivatives (3a-g) and substituted a-bromo-1, 2-(substituted) diaryl-1-ethanones (7a-i). The structures of the synthesized compounds were established by IR, 1H NMR, 13C NMR and mass spectroscopical data. The compounds (8a-y) were evaluated for their in-vitro cytotoxic activity on murine (B16F10) and human (MCF-7) cancer cells by using MTT assay. From the in vitro studies compounds 8p, 8u and 8y were found most effective with an IC50 range of 0.56-27.50 μM in MCF-7 and 2.57-36.54 μM in B16F10 cells.