33420-82-5

Upstream product

• 100-68-5 methyl-phenyl-thioether 
• 4693-91-8 4-methoxyphenyl-acetic chloride 
• 104-95-0 (4-bromophenyl)thioanisole 
• 19625-79-7 N,N-dimethyl-2-(4-methoxyphenyl)ethanamide 
• 23786-14-3 4-methoxy-phenyl acetic acid methyl ester 
• 104-01-8 4-Methoxyphenylacetic acid 

Downstream Products

• 177755-62-3 1-(4-methoxyphenyl)-2-[4-(methylthio)phenyl]ethane-1,2-dione 
• 33420-83-6 1-(4-Methanesulfonyl-phenyl)-2-(4-methoxy-phenyl)-ethanone 
• 33420-84-7 1-(4-Methanesulfonyl-phenyl)-2-(4-methoxy-phenyl)-ethane-1,2-dione 
• 1313411-36-7 C₁₈H₁₆N₄O₃S₃ 
• 1313411-39-0 C₂₄H₁₈FN₃OS₂ 
• 1313411-43-6 C₂₅H₂₁N₃O₂S₂ 
• 1542256-76-7 5-(4-methoxyphenyl)-6-(4-(methylsulfonyl)phenyl)-3-(methylthio)-1,2,4-triazine 
• 1542256-66-5 C₁₆H₁₅NO₅S 
• 1542256-71-2 C₁₇H₁₅N₃O₃S₂ 
• 1370409-52-1 2-(4-methoxyphenyl)-3-[4-(methylsulfanyl) phenyl]imidazo[2,1-b][1,3]benzothiazole-7-carboxylic acid 
• 1370024-14-8 7-bromo-2-(4-methoxyphenyl)-3-[4-(methylsulfanyl)phenyl] imidazo[2,1-b][1,3] benzothiazole 
• 1370409-55-4 2-(4-methoxyphenyl)-3-[4-(methylsulfanyl)phenyl]-7-nitroimidazo[2,1b][1,3] benzothiazole 
• 877224-40-3 C₁₇H₁₉N₃O₄S 
• 301693-60-7 2,2-dimethyl-4-(4-methoxyphenyl)-5-[4-(methylthio)phenyl]-3(2H)-furanone 

Relevant academic research and scientific papers

Continuous Flow Acylation of (Hetero)aryllithiums with Polyfunctional N,N-Dimethylamides and Tetramethylurea in Toluene

The continuous flow reaction of various aryl or heteroaryl bromides in toluene in the presence of THF (1.0 equiv) with sec-BuLi (1.1 equiv) provided at 25 °C within 40 sec the corresponding aryllithiums which were acylated with various functionalized N,N-

An efficient and time saving microwave-assisted selenium dioxide oxidation of 1,2-diarylethanones

Selenium dioxide oxidation of 1,2-diarylethanones to corresponding diones by conventional method takes upto 8 hr. The same oxidation under microwave radiations using dimethylsulfoxide as solvent reduces the reaction time considerably (30 to 90 sec). The method reported is efficient and time saving.

Syntheses of 4,5-diaryl-1,2,3-thiadiazoles

Reaction of thionyl chloride with semicarbazones of 1-(4- methylsulfonylphenyl)-2-(4-substituted pheny)lethanone gave 4-(4- methylsulfonylphenyl)-5-(4-substituted) pheny-1,2,3-thiadiazoles 5. Compounds 5-phenyl-4-(substitutedphenyl)-1,2,3-thiadiazoles 14 were similarly prepared. Chlorosulfonation of the latter followed by ammonia gave the desired compounds 5-(4-aminosulfonylphenyl)-4-(substituted) phenyl-1,2,3-thiadiazoles 6. Copyright Taylor & Francis Inc.

Synthesis and biological evaluation of 2,3-diarylpyrazines and quinoxalines as selective COX-2 inhibitors

Several 2,3-diaryl pyrazines and quinoxalines with 4-sulfamoyl (SO 2NH2)/methylsulfonyl (SO2Me)-phenyl pharmacophores have been synthesized and evaluated for the cyclooxygenase (COX-1/COX-2) inhibitory activity. Smaller groups such as methoxy, methyl and fluoro when substituted at/around position-4 of the adjacent phenyl ring, have great impact on the selective COX-2 inhibitory activity of the series. Many potential compounds were obtained from a brief structure-activity relationship (SAR) study. Two of these, compounds 11 and 25 exhibited excellent in vivo activity in the established animal model of inflammation. Since compound 25 possessed an amenable sulfonamide group, two of its prodrugs 48 and 49 were also synthesized. Both of them have excellent in vivo potential, and represent a new class of COX-2 inhibitor.

A high speed parallel synthesis of 1,2-diaryl-1-ethanones via a clean-chemistry C-C bond formation reaction

In this report, we describe the parallel as well as conventional synthesis of 1,2-diaryl-1-ethanones via environmentally benign acylation of arenes with in situ generated arylacetyl trifluoroacetates. A wide variety of arylacetic acids I participated in trifluoroacetic anhydride/phosphoric acid mediated C-C bond formation reaction when reacted with arenes of type II to give 1,2-diaryl-1-ethanones III in good to excellent yield. Under the solvent-free conditions these chemical transformations that normally require longer reaction time can be performed within minutes in good yield.