1370549-55-5Relevant academic research and scientific papers
Palladium-catalyzed highly regioselective Mizoroki-heck arylation of allylamines with aryl chlorides
Zhang, Lingjuan,Jiang, Zhen,Dong, Chaonan,Xue, Xiao,Qiu, Ruiying,Tang, Weijun,Li, Huanrong,Xiao, Jianliang,Xu, Lijin
, p. 311 - 318 (2014/01/23)
Palladium catalyst systems for the regioselective Mizoroki-Heck arylation of N,N-diprotected and N-protected allylamines with aryl chlorides have been developed. Pd(OAc)2 in combination with appropriate additives could efficiently catalyze the linear arylation of N,N-diprotected allylamines with aryl chlorides in toluene to give exclusively the γ-arylated products in good to excellent yields and with excellent regio- and stereocontrol and good functional group tolerance. With use of a catalytic mixture of Pd(OAc) 2 and 1,1'-bis(diphenylphosphino)ferrocene, the arylation of N-protected allylamines with aryl chlorides could be accomplished in ethylene glycol/DMSO, which afforded complete β-regioselectivity with good functional group tolerance. The steric and electronic properties of allylamine substrates are found to be critical to the catalytic activity and regiocontrol in both linear and internal arylations. Copyright
Palladium-catalyzed, highly efficient, regiocontrolled arylation of electron-rich allylamines with aryl halides
Deng, Yuheng,Jiang, Zhen,Yao, Min,Xu, Dan,Zhang, Lingjuan,Li, Huanrong,Tang, Weijun,Xu, Lijin
experimental part, p. 899 - 907 (2012/05/04)
The highly efficient and regioselective palladium-catalyzed Heck coupling of aryl bromides with electron-rich allylamine derivatives is described. It was found that the choice of solvent, olefin, ligand and additive had a fundamental influence on the regi
Palladium-catalyzed highly regioselective and stereoselective arylation of electron-rich allylamines with aryl bromides
Jiang, Zhen,Zhang, Lingjuan,Dong, Chaonan,Ma, Baode,Tang, Weijun,Xu, Lijin,Fan, Qinghua,Xiao, Jianliang
experimental part, p. 4919 - 4926 (2012/07/28)
A palladium-catalyzed, highly efficient Heck arylation of electron-rich N,N-diprotected allylamine derivatives with a wide range of aryl bromides under ligand-free conditions has been developed. In the presence of Pd(OAc) 2 and an appropriate a
