137057-36-4

Upstream product

• 75424-49-6 (E)-6-Bromhex-2-encarbonsaeuremethylester 
• 629-11-8 1,6-hexanediol 
• 190522-49-7 E-8-phenyl-8-oxo-6-octenal 
• 33803-62-2 6-(tetrahydropyrane-2-yloxy)hexan-1-al 
• 871468-89-2 (1S,2S)-2-(2-oxo-2-phenylethyl)-cyclopentanecarbaldehyde 
• 871468-90-5 (1R,2S)-2-(2-oxo-2-phenylethyl)-cyclopentanecarbaldehyde 
• 4525-33-1 dimethyl dicarbonate 
• 186581-53-3 diazomethane 
• 28659-22-5 6-(tetrahydro-2H-pyranyloxy)hexan-1-ol 
• 871468-86-9 3-hydroxy-1-phenyl-8-(tetrahydropyran-2-yloxy)-octan-1-one 
• 871468-87-0 1-phenyl-8-(tetrahydropyran-2-yloxy)-oct-2-en-1-one 
• 871468-88-1 (E)-8-hydroxy-1-phenyloct-2-en-1-one 

Relevant academic research and scientific papers

Cysteine-derived organocatalyst in a highly enantioselective intramolecular Michael reaction

Asymmetric intramolecular Michael reaction catalyzed by an organocatalyst derived from cysteine has been developed for the synthesis of chiral bicyclo[4.3.0]nonene and cis-disubstituted cyclopentane skeletons with a creation of three or two contiguous chiral centers in good yield with high diastereo- and excellent enantioselectivities. Copyright

Catalytic asymmetric reductive Michael cyclization

A highly efficient and chemo-, regio-, diastereo-, and enantioselective organocatalytic tandem conjugate reduction-Michael cyclization of enal enones has been developed. Accordingly, treating the enal enone with a Hantzsch dihydropyridine in the presence

Diastereo- and Enantioselective Synthesis of 1,2-trans-substituted Cycloalkanecarboxylates and Sulfones by Michael-Initiated Cyclisation via SAMP/RAMP Hydrazones

An efficient and flexible synthesis of 1,2-trans-substituted cycloalkanecarboxylates and sulfones of high diastereo- and enantiomeric purity is described.The key step of the procedure is a Michael-initiated ring closure (MIRC) reaction employing the SAMP/RAMP hydrazone method.Depending on the chain length of the ω-bromo(iodo)enoates 2,3 and the type of ketone SAMP-hydrazone 1, 3-, 5-, 6- and 7-membered cycloalkanecarboxylates 4-7 or cyclopentanesulfones 24 bearing two or three stereogenic centers are formed with very high asymmetric induction.In the same manner, MIRC reactions with ω-(ethoxycarbonyl)enoate 26 give rise to 3-substituted cyclopentanone-2-carboxylates 27, but with lower overall chemical yields.The relative and absolute configurations are based on X-ray structure analysis, spectroscopic and mechanistic investigations. - Key Words: SAMP Hydrazones / RAMP Hydrazones / MIRC reactions / Cycloalkanecarboxyl acid esters / Sulfones