190522-49-7Relevant academic research and scientific papers
Cysteine-derived organocatalyst in a highly enantioselective intramolecular Michael reaction
Hayashi, Yujiro,Gotoh, Hiroaki,Tamura, Tomohiro,Yamaguchi, Hirofumi,Masui, Ryouhei,Shoji, Mitsuru
, p. 16028 - 16029 (2007/10/03)
Asymmetric intramolecular Michael reaction catalyzed by an organocatalyst derived from cysteine has been developed for the synthesis of chiral bicyclo[4.3.0]nonene and cis-disubstituted cyclopentane skeletons with a creation of three or two contiguous chiral centers in good yield with high diastereo- and excellent enantioselectivities. Copyright
Antibody-catalyzed asymmetric intramolecular Michael addition of aldehydes and ketones to yield the disfavored cis-product
Weinstain, Roy,Lerner, Richard A.,Barbas III, Carlos F.,Shabat, Doron
, p. 13104 - 13105 (2007/10/03)
The development of new catalytic asymmetric reactions continues to be a major goal in organic chemistry. Here we report a novel antibody-catalyzed intramolecular Michael addition of aldehydes and ketones to enones. The reaction is enantioselective and dia
Assessing the scope of the tandem Michael/intramolecular aldol reaction mediated by secondary amines, thiols and phosphines
Richards, Elinor L,Murphy, Patrick J,Dinon, Francesca,Fratucello, Silvia,Brown, Paul M,Gelbrich, Thomas,Hursthouse, Michael B
, p. 7771 - 7784 (2007/10/03)
The outcome of a tandem Michael/intramolecular aldol reaction which is mediated by secondary amines, thiols and phosphines has been found to be highly substrate dependent, with the best results being obtained for the formation of 5 and 6-membered rings using thiol or thiolate nucleophiles. Amine and phosphine mediated cyclisations were found to be problematic in several cases but were still effective methods for the formation of 5-7 membered rings.
