13707-43-2

Upstream product

• 55596-11-7 N-(2,2,2-trichloroethylidene)benzenesulfonamide 
• 21326-49-8 complex of sulfur dioxide with dimethylamine 
• 13909-34-7 N-benzylidenephenylsulfonamide 
• 23879-26-7 1-phenyl-4-dimethylamino-2-phenyl-1,3-diazabutadiene 
• 108228-47-3 1-p-tolyl-4-dimethylamino-2-phenyl-1,3-diazabutadiene 
• 473-29-0 N,N-Dichlorobenzenesulfonamide 
• 2618-96-4 dibenzenesulfonamide 
• 68-12-2 N,N-dimethyl-formamide 
• 98-09-9 benzenesulfonyl chloride 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 98514-83-1 N-(pyridine-2-ylmethyl)benzenesulfonamide 
• 938-10-3 phenylsulfonyl azide 
• 10448-42-7 dimethyl-styryl-amine 
• 103-83-3 N,N'-dimethylbenzylamine 

Relevant academic research and scientific papers

Preparation method of sulfonyl amidine with 2-Picolylamine and DMF-DMA as amine sources

The invention discloses a preparation method of sulfonyl amidine with 2-Picolylamine and DMF-DMA as amine sources. The method comprises the following steps: reacting sulfonyl chloride with 2-Picolylamine to obtain an intermediate product; and then reacting the intermediate product with DMF-DMA in the presence of a catalyst at a temperature of 60-100 DEG C, then performing cooling to room temperature, extracting the reaction solution with ethyl acetate, performing layering, drying and then concentrating to obtain a target product sulfonyl amidine. According to the method disclosed by the invention, the reaction of secondary sulfonamide and DMF-DMA is realized, and the synthesis path of sulfonyl amidine is expanded. The synthetic reaction is simple in operation, mild in condition and convenient in post-treatment, and the obtained intermediate product and the product are high in purity and yield.

N -Sulfonyl acetylketenimine as a highly reactive intermediate for the synthesis of N -sulfonyl amidines

A highly reactive intermediate N-sulfonyl acetylketenimine was generated from a 3-butyn-2-one participating CuAAC/ring-opening method. Its high reactivity due to bearing two EWGs allowed us to offer the first example of a reaction between ketenimine and amide to synthesize N-sulfonyl amidines efficiently.

A Novel Synthesis of N -Sulfonylformamidines from N Sulfonyl sulfonamides

N -Sulfonylformamidines were synthesized from N -sulfonylsulfonamides by reacting with p -toluenesulfonyl chloride (TsCl) and N, N - disubstituted formamides. In this reaction, it was expected that mixing TsCl with the N, N -disubstituted formamide would generate an iminium salt (Vilsmeier reagent). The reaction avoids the use of metal catalysts and hazardous reagents, and the desired N -sulfonylformamidines were obtained in 60% to quantitative yields.

Mild reductive functionalization of amides into N-sulfonylformamidines

The development of a protocol for the reductive functionalization of amides into N-sulfonylformamidines is reported. The one-pot procedure is based on a mild catalytic reduction of tertiary amides into the corresponding enamines by the use of Mo(CO)6 (molybdenum hexacarbonyl) and TMDS (1,1,3,3-tetramethyldisiloxane). The formed enamines were allowed to react with sulfonyl azides to give the target compounds in moderate to good yields.

Unexpected C=N bond formation via NaI-catalyzed oxidative de-tetra-hydrogenative cross-couplings between N,N-dimethyl aniline and sulfamides

A direct and convenient C=N bond formation reaction was reported, which was a de-tetra-hydrogenative cross-coupling (DTCC) reaction between N,N-dimethyl aniline and sulfamide under transition-metal-free conditions, and to give sulfonyl amidine derivatives in moderate to high yields.

Metal- and solvent-free synthesis of N-sulfonylformamidines

A solvent-free green synthesis of N-sulfonylformamidines is reported via the direct condensation of N,N-dimethylformamide dimethyl acetal (DMF-DMA) and sulfonamide derivatives at room temperature. The described method avoids the use of metal catalysts as

Otherwise inert reaction of sulfonamides/carboxamides with formamides via proton transfer-enhanced reactivity

NBS-mediated addition-elimination reaction of sulfonamides/carboxamides and formamides afforded N-sulfonylamidines and N-formylarylamides, respectively, depending on the different mechanism of elimination. Hydrogen bond-induced proton transfer leads to en

Unexpected route for the synthesis of N,N-dialkyl formamidines using phenyl chloroformate and N,N-dialkyl formamides

An unexpected route for the synthesis of N,N-dialkyl formamidines has been reported by the reaction of amines with N,N-dialkyl formamides and phenyl chloroformate.

Direct condensation of sulfonamide and formamide: NaI-catalyzed synthesis of N-sulfonyl formamidine using TBHP as oxidant

A new N-sulfonyl formamidine synthesis was developed via NaI-catalyzed direct condensation of sulfonamide and formamide. The green methodology is featured by high atom economy, easily available starting materials, the lack of need for a transition-metal c

Reactivity of 1-aryl-4-dimethylamino-2-phenyl-1,3diaza-1,3-butadienes towards dienopheles, 1,3-dipoles and carbanions

The reactivity of 1-aryl-4-dimethylamino-2-phenyl-1,3-diaza-1,3-butadienes (1) towards dienophiles, 1,3-dipoles and C-nucleophiles was investigated. N-Phenylmethylene-benzenesulfonamide (2), phenylisocyanate (6), C,N-diphenylnitrone (9) and acylacetates (10) reacted with 1 giving quinazoline or pyrimidine derivatives. The possible mechanisms involved in products formation are discussed.