1370723-74-2

Upstream product

• 459-57-4 4-fluorobenzaldehyde 
• 719-59-5 5-chloro-2-aminobenzophenone 
• 123-54-6 acetylacetone 
• 22609-02-5 1-(6-chloro-2-methyl-4-phenylquinolin-3-yl)ethanone 

Downstream Products

• 1244950-80-8 C₃₁H₂₃ClFN₃ 

Relevant academic research and scientific papers

Environmentally Friendly Nafion-Mediated Friedl?nder Quinoline Synthesis under Microwave Irradiation: Application to One-Pot Synthesis of Substituted Quinolinyl Chalcones

An efficient and eco-friendly synthetic route for Friedl?nder quinoline synthesis of polysubstituted quinolines is described. This green chemical method starts from various 2-aminobenzophenones and mono- or dicarbonyl synthons and uses reusable Nafion NR50 material as a solid catalyst in ethanol under microwave irradiation. The protocol has a high generality of functional groups and provides the desired quinolines in good to excellent yields. Some structures were confirmed by single-crystal X-ray diffraction analysis.

An efficient microwave assisted eco-friendly synthesis of 6-chloro-3-(3-arylacryloyl)-2-methyl-4-phenylquinolines and their conversion to 6-chloro-3-(1-phenyl-5-aryl-4,5-dihydro-1h-pyrazol-3-yl)-2-methyl-4- phenylquinolines

An eco-friendly basic alumina catalyzed protocol for the synthesis of some new quinolinyl chalcones has been developed by microwave assisted methods which in turn are converted to pyrazoline derivatives.