1370729-76-2

Upstream product

• 703-61-7 2,4-dichloroquinoline 
• 35132-20-8 (R,R)-1,2-diphenylethylenediamine 
• 123-75-1 pyrrolidine 
• 1370729-78-4 (1R,2R)-N₁,N₂-bis(4-chloroquinolin-2-yl)-1,2-diphenylethane-1,2-diamine 

Downstream Products

• 1370729-77-3 (1R,2R)-1,2-diphenyl-N₁,N₂-bis(4-(pyrrolidin-1-yl)quinolin-2-yl)ethane-1,2-diamine bistrifluoromethanesulfonimide 

Relevant academic research and scientific papers

Achiral counterion control of enantioselectivity in a Bronsted acid-catalyzed lactonization

Highly enantioselective halolactonizations have been developed that employ a chiral proton catalyst-N-iodosuccinimide (NIS) reagent system in which the Bronsted acid is used at catalyst loadings as low as 1 mol %. An approach that modulates the achiral counterion (equimolar to the neutral chiral ligand-proton complex present at low catalyst loadings) to optimize the enantioselection is documented for the first time in this transformation. In this way, unsaturated carboxylic acids are converted to γ-lactones in high yields (up to 98% ee) using commercially available NIS.