137092-17-2Relevant academic research and scientific papers
Method for preparing vortioxetine
-
Paragraph 0011; 0026, (2017/08/30)
The invention discloses a method for preparing vortioxetine. The preparation method comprises the following steps: enabling 2-bromobenzenamine to react with sodium nitrite so as to obtain a reactive intermediate in the presence of concentrated sulfuric acid; carrying out a reaction with piperazine to obtain an intermediate A, performing alkali regulation on the intermediate A, and synthesizing with 2,4-dimethylthiophenol, thereby obtaining the target product vortioxetine. The method is short in synthetic route, simple in process, high in product yield, and suitable for industrialized production. The structural formula is as shown in the specification.
