137160-74-8

Upstream product

• 96-20-8 2-aminobutanol 
• 137160-76-0 acetone O-(benzyloxycarbonyl)oxime 
• 501-53-1 benzyl chloroformate 

Downstream Products

• 113829-86-0 (R)-(+)-2-(benzyloxycarbonylamino)butyl acetate 
• 113829-87-1 (S)-(-)-2-(benzyloxycarbonylamino)butyl acetate 
• 145799-48-0 (R)-(+)-benzyl 2-(benzyloxycarbonylamino)butyl carbonate 
• 145799-48-0 (S)-(-)-benzyl 2-(benzyloxycarbonylamino)butyl carbonate 

Relevant academic research and scientific papers

RHO KINASE INHIBITOR, METHOD FOR PREPARING SAME AND USES THEREOF

Provided are a Rho kinase inhibitor, a method for preparing same and the uses thereof. The Rho kinase inhibitor designates a compound of Formula I, a stereoisomer thereof or pharmaceutically acceptable salt thereof. The Rho kinase inhibitor promotes endothelial cells and endothelin expression, prostenin expression, and vascular factors NO synthesis and secretion, has a promoting effect on proprostin expression independently of the doses used, shows lower toxicity, while being safer.

Oxime esters as acylating agents in the aminolysis reaction. A simple and chemoselective method for the preparation of amides from amino alcohols

Oxime esters, such as acetone O-alkanoyl-, O-alkenoyl- or O-benzyloxycarbonyloximes, react with amines under extremely mild conditions to give the corresponding amides in very good yield. When amino alcohols are used a total chemoselectivity is observed.

1-N-substituted derivatives of 4,6-di-O-(aminoglycosyl)-1,3-diaminocyclitols

Novel 1-N-aminoalkyl (oxycarbonyl or carboxamido or thiocarboxamido) derivatives of 4,6-di-O-(aminoglycosyl)-1,3-diaminocyclitols, useful as antibacterial agents, are described.