137208-84-5Relevant academic research and scientific papers
Triazolopyrimidine derivative compounds
-
Paragraph 0018; 0078, (2017/05/18)
PROBLEM TO BE SOLVED: To provide a FABP4 probe having low lipid solubility and capable of specifically binding to FABP4.SOLUTION: This invention relates to a triazolopyrimidine derivative compound comprising a fluorine atom or salt thereof, and a pharmaceutical composition comprising the same.
Peptide deformylase inhibtors
-
, (2008/06/13)
The present invention involves novel anti-bacterial compounds represented by Formula (I) hereinbelow and their use as PDF inhibitors. The present invention further provides methods for inhibiting PDF in an animal, including humans, which comprises administering to a subject in need of treatment an effective amount of a compound of Formula (I) as indicated hereinbelow.
Compounds having one or more aminosulfaonyloxy radicals useful as pharmaceuticals
-
, (2008/06/13)
Methods of treating chronic arthritis and osteoporosis which utilize both known and novel compounds which would fall under the general formula:(HO)p--A--[--OS(O) 2 NR 1 R 2 ] zwherein A encompasses a wide range of values including but not limited to aryl, loweralkyl, cycloalkyl, and carbohydrates including sucrose and fructose; p is equal to the number of unreacted hydroxy groups contained on the molecule and may be zero; z is the number of --OS(O) 2 NR 1 R 2 groups and is always at least one; R 1 and R 2 are selected from hydrogen, loweralkyl, carboxy and the like; a novel process for preparing the compounds is provided wherein an appropriate sulfamic acid aryl ester is reacted with a hydroxy substituted A radical which may or may not contain thereon protected carboxyl, amino or hydroxy substituents, in an aprotic solvent containing a tertiary amine base. Pharmaceutical compositions for the treatment of chronic arthritis and osteoporosis are also provided.
