137234-73-2Relevant academic research and scientific papers
Selective fluorination of pyridine and its derivatives in the presence of high-oxidation-state transition metals
Gryaznova,Khrizanforova,Kholin,Khrizanforov,Budnikova, Yu. H.
, p. 1798 - 1804 (2016)
The oxidative fluorination of pyridine and 4-ethylpyridine under chemical and electro-chemical conditions in the presence of transition metal (high-oxidation-state nickel, cobalt, and silver) salts was studied. The chemical fluorination affords 2-fluoropyridine in all cases, while the electrochemical fluorination results in 2-fluoroor 3-fluoropyridine depending on the catalyst used.
Tetrahydronaphthyridine derivates useful as histamine H3 receptor ligands
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Page/Page column 60-61, (2008/06/13)
The invention relates to tetrahydronaphthyridine derivatives having formula (I) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. Said tetrahydronaphthyridine derivatives are H3 ligands and are useful in numerous diseases, disorders and conditions, in particular inflammatory, allergic and respiratory diseases, disorders and conditions.
Novel antifungal 2-aryl-1-(1H-1,2,4-triazol-1-yl)butan-2-ol derivatives with high activity against Aspergillus fumigatus
Dickinson, Roger P.,Bell, Andrew S.,Hitchcock, Christopher A.,Narayanaswami, Subramaniyan,Ray, Stephen J.,Richardson, Kenneth,Troke, Peter F.
, p. 2031 - 2036 (2007/10/03)
Replacement of one triazole ring of fluconazole with 4-pyridinyl leads to an increase in activity against Aspergillus fumigatus. Introduction of an α-methyl group has a marked additional beneficial effect. Investigation of pyridinyl and pyrimidinyl analogues resulted in the identification of 30 (UK-109,496), voriconazole) which has excellent potency against a broad range of fungal pathogens including A. fumigatus and Candida krusei.
Triazole antifungal agents
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, (2008/06/13)
The invention provide antifungal compounds of the formula: STR1 and pharmaceutically acceptable salts thereof, wherein R is phenyl substituted by 1 to 3 substituents each independently selected from halo, --CF3 and --OCF3 ; R1 is C1 -C4 alkyl; R2 is H or C1 -C4 alkyl; X is CH or N; and Y is F or Cl.
