1372609-11-4Relevant academic research and scientific papers
PROCESSES FOR PREPARATION OF LUBIPROSTONE
-
Paragraph 0055, (2016/11/17)
PROBLEM TO BE SOLVED: To provide new processes for preparing and purifying lubiprostone. SOLUTION: A process involves 1,4-conjugate addition of a higher order cuprate compound to a protected cyclopentenone intermediate as an important preparation step. Obtained lubiprostone is converted into a guanidine salt derivative that possesses a different melting point and solubility than lubiprostone, and thereby lubiprostone is refined. A novel synthetic intermediate is also present. COPYRIGHT: (C)2015,JPOandINPIT
PROCESSES FOR PREPARATION OF LUBIPROSTONE
-
, (2012/05/04)
Processes for preparing and purifying lubiprostone are disclosed. Intermediates and preparation thereof are also disclosed.
