1372679-41-8

Upstream product

• 143540-05-0 2-hydroxymethylpiperazine-1,4-dicarboxylic acid di-tert-butyl ester 
• 1246551-25-6 tert-butyl 3-oxo-1,2,5,6,8,8a-hexahydroimidazo[1,5-a]pyrazine-7-carboxylate 
• 586-78-7 para-nitrophenyl bromide 
• 1256815-07-2 di-tert-butyl 2-(aminomethyl)piperazine-1,4-dicarboxylate 
• 1256815-06-1 di-tert-butyl 2-((1,3-dioxoisoindolin-2-yl)methyl)-piperazine-1,4-dicarboxylate 

Downstream Products

• 1372679-57-6 hexahydro-2-(4-nitrophenyl)-imidazo[1,5-a]pyrazin-3-one 

Relevant academic research and scientific papers

Convenient synthesis of novel 2-substituted imidazopyrazinone derivatives

Starting from commercially available piperazine-2-carboxylic acid, a series of novel 2-aryl and 2-benzyl substituted imidazopyrazinone were prepared. The intermediates 5a-g were obtained through facile Buchwald-Hartwig coupling reaction, and the effects of catalyst, base, and solvent on the coupling reaction were investigated. The optimal reaction conditions for the coupling reaction were PdCl2(dppf)=NaO-t-Bu=toluene. Taylor & Francis Group, LLC.