137272-68-5

Upstream product

• 1382312-69-7 2-bromo-3-thiophenecarboxylic acid-2-pyridyl ester 
• 75-16-1 methylmagnesium bromide 
• 88-13-1 3-Thiophene carboxylic acid 
• 676-58-4 methylmagnesium chloride 
• 24287-95-4 2-bromothiophene-3-carboxylic acid 
• 24287-92-1 2-Bromo-3-iodothiophene 
• 108-24-7 acetic anhydride 

Relevant academic research and scientific papers

Dithiophene rotor derivative 3'-acetyl-[2,2'-dithiophene]-3-formaldehyde as well as preparation method and application thereof

The invention belongs to the technical field of material synthesis, and provides a bithiophene rotor derivative 3'-acetyl-[2,2'-dithiophene]-3-formaldehyde as well as a preparation method and application thereof. The structural formulthe is shown in the specification, wherein the bithiophene rotor derivative 3'-acetyl-[2,2'-dithiophene]-3-formaldehyde is synthesized by adopting the method for controlling relaxation and conjugation of molecular rotor conformation, and wherein the rotors with different torsion angles and conjugate degrees generate different light emitting colors. In addition, hydrogen bond stimulation can easily overcome the rotational energy barrier between the torsional conformation and the near-plane conformation. An aldehyde group is introduced to one side of bithiophene as the hydrogen bond site, so that the luminescence response of driving the rotor to rotate under the stimulation of the hydrogen bond is realized. The method is of great significance to reasonable design of molecular rotors and stimuli-responsive luminescent materials. The material has important application value in the fields of photoelectric displays, fluorescence sensors, memory storage chips, organic conductive materials, solar energy conversion, optical logic gates and the like.

TRICYCLIC COMPOUND SERVING AS IMMUNOMODULATOR

Provided are compounds of formula I and formula II or pharmaceutically acceptable salts of the compounds and pharmaceutical compositions thereof. The compounds of formula I and formula II or the pharmaceutically acceptable salts of the compounds provide indole 2,3-dioxygenase (IDO) inhibitory activity and are capable of treating IDO-mediated immunosuppressive diseases, such as infectious diseases or cancer.

Synthesis of 2,3-Substituted Thienylboronic Acids and Esters

A noncryogenic protocol for the synthesis of 2-substituted 3-thienylboronic acids and esters as well as 3-substituted 2-thienylboronic acids and esters has been developed. Electrophiles were introduced regiospecifically in the 2-position of 2,3-dibromothiophene and in the 3-position of 2-bromo-3-iodothiophene by halogen-magnesium exchange followed by quenching with electrophiles. Palladium-catalyzed borylation of the 2,3-substituted halothiophenes with pinacolborane and P(t-Bu)3 as ligand for Pd produced 9 and 10. The borylation protocol was tolerated by a range of functional groups; however, strongly electron-withdrawing substituents decreased the stability of the thienylboronic acids and esters.