137278-30-9Relevant academic research and scientific papers
E-olefin dipeptide isostere incorporation into a polypeptide backbone enables hydrogen bond perturbation: Probing the requirements for Alzheimer's amyloidogenesis
Fu, Yanwen,Bieschke, Jan,Kelly, Jeffery W.
, p. 15366 - 15367 (2007/10/03)
Herein, we report a stereospecific E-olefin dipeptide isostere synthesis that can be used to make gram quantities of the Phe-Phe isostere desired for eliminating a specific backbone H-bond donor and acceptor in the Alzheimer's disease related Aβ peptide.
Stereoselective Epoxidation of Phe-Gly and Phe-Phe Vinyl Isosteres
Jenmalm, Annika,Berts, Wei,Li, Yi-Lin,Luthman, Kristina,Csoeregh, Ingeborg,Hacksell, Uli
, p. 1139 - 1148 (2007/10/02)
Novel Phe-Gly and Phe-Phe isosteres have been synthesized.Vinylic isosteres of Phe-Gly and Phe-Phe were prepared by facile Julia reactions, and the resulting stereoisomers were isolated and epoxidized (m-chloroperbenzoic acid).Observed stereoselectivities
"Higher Order" Zinc Cuprates Involving Lithium Chloride: Synthesis of (E)-Alkene Dipeptide Isosteres Free from Reductive Elimination Products
Ibuka, Toshiro,Yoshizawa, Hidenori,Habashita, Hiromu,Fujii, Nobutaka,Chounan, Yukiyasu,et al.
, p. 3783 - 3786 (2007/10/02)
The "higher order" organozinc cuprates, R2Cu(CN)(ZnCl)2*2Mg(X)Cl*nLiCl, derived from admixture of LiCl (1-2 equi.), ZnCl2 (1 equiv.), RMgX (1 equiv.), and CuCN (0.5 equiv.) in a mixed solvent of THF and Et2O exhibit high diastereoselection of up to >99:1
