1372791-22-4

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 99-92-3 p-aminobenzophenone 
• 232597-42-1 tert-butyl 4-acetylphenylcarbamate 
• 42059-30-3 1-azido-2-iodoethane 
• 885269-70-5 tert-butyl N-[4-(2-bromoacetyl)phenyl]carbamate 

Downstream Products

• 1372791-20-2 C₂₇H₃₃N₃O₄ 
• 1372791-24-6 (E)-4-(4-(4-aminobenzylidene)-3,4-dihydro-2H-pyrrol-5-yl)aniline 
• 1372791-21-3 (E)-2-chloro-N-(4-(4-(4-(2-chloroacetamido)benzylidene)-3,4-dihydro-2H-pyrrol-5-yl)phenyl)acetamide 

Relevant academic research and scientific papers

Reversible photocontrol of peptide conformation with a rhodopsin-like photoswitch

Reversible photocontrol of biomolecules requires chromophores that can efficiently undergo large conformational changes upon exposure to wavelengths of light that are compatible with living systems. We designed a benzylidene-pyrroline chromophore that mimics the Schiff base of rhodopsin and can be used to introduce light-switchable intramolecular cross-links in peptides and proteins. This new class of photoswitch undergoes an ～10 A change in end-to-end distance upon isomerization and can be used to control the conformation of a target peptide efficiently and reversibly using, alternately, violet (400 nm) and blue (446 nm) light.