1372807-97-0

Basic information

• Product Name: (S)-2-(4-methoxybenzyl)-4-(4-nitrobenzyl)-5-isobutyl-1,2,4-triazine-3,6-dione
• Synonyms: (S)-2-(4-methoxybenzyl)-4-(4-nitrobenzyl)-5-isobutyl-1,2,4-triazine-3,6-dione
• CAS NO: 1372807-97-0
• Molecular Weight: 426.472
• Mol File: 1372807-97-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-2-(4-methoxybenzyl)-4-(4-nitrobenzyl)-5-isobutyl-1,2,4-triazine-3,6-dione(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-(4-methoxybenzyl)-4-(4-nitrobenzyl)-5-isobutyl-1,2,4-triazine-3,6-dione(1372807-97-0)
• EPA Substance Registry System: (S)-2-(4-methoxybenzyl)-4-(4-nitrobenzyl)-5-isobutyl-1,2,4-triazine-3,6-dione(1372807-97-0)

Safety Data

• Hazardous Substances Data: 1372807-97-0(Hazardous Substances Data)

Upstream product

• 1372807-64-1 C₂₈H₃₈N₄O₈ 
• 7517-19-3 methyl (L)-leucinate hydrochloride 
• 555-16-8 4-nitrobenzaldehdye 
• 123-11-5 4-methoxy-benzaldehyde 
• 150767-00-3 N-t-butoxycarbonyl-N'-4-methoxybenzaldehyde hydrazone 
• 150767-02-5 N-1-(tert-butoxycarbonyl)-N-2-<(4-methoxyphenyl)methyl>hydrazine 
• 34632-27-4 (S)-4-Methyl-2-{[1-(4-nitro-phenyl)-meth-(Z)-ylidene]-amino}-pentanoic acid methyl ester 

Relevant articles and documents

Combinatorial aid for underprivileged scaffolds: Solution and solid-phase strategies for a rapid and efficient access to novel aza-diketopiperazines (aza-DKP)

An efficient solution-phase synthesis of aza-diketopiperazines (aza-DKP, triazinediones) is reported. A structurally diverse collection of c-[aza-alkylGly-Pro] derivatives and yet unreported 2,4,5-trisubstituted-1,2,4- triazine-3,6-diones has been synthesized starting from Fmoc-l-Pro-OH and various Fmoc-l-amino acids. To extend the practical value of this class of dipeptidomimetics, a general solid-phase synthesis approach amenable to library production was developed on both Wang-PS and HMBA-PS resins. The final acidic treatment of the resins in TFA/water mixture at room temperature enabled the rapid and quantitative cyclization/release highly pure triazinediones. The conformational preferences and the spatial organization of the three substituents of a representative 2,4,5-trisubstituted-1,2,4-triazine-3,6-dione were investigated by X-ray diffraction and 1H NMR spectroscopy.