150767-02-5

Basic information

• Product Name: Tert-butyl N-[(4- Methoxyphenyl)MethylaMino]carbaMate
• Synonyms: Tert-butyl N-[(4- Methoxyphenyl)MethylaMino]carbaMate;Hydrazinecarboxylic acid, 2-[(4-Methoxyphenyl)Methyl]-, 1,1-diMethylethyl ester;tert-butyl 2-(4-Methoxybenzyl)hydrazinecarboxylate;N-1-(tert-butoxycarbonyl)-N-2-hydrazine;tert-butyl 2-(4-methoxybenzyl)hydrazine-1-carboxylate
• CAS NO: 150767-02-5
• Molecular Formula: C₁₃H₂₀N₂O₃
• Molecular Weight: 252.3095
• Mol File: 150767-02-5.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• Density: 1.080±0.06 g/cm3(Predicted)
• PKA: 10.45±0.43(Predicted)
• CAS DataBase Reference: Tert-butyl N-[(4- Methoxyphenyl)MethylaMino]carbaMate(CAS DataBase Reference)
• NIST Chemistry Reference: Tert-butyl N-[(4- Methoxyphenyl)MethylaMino]carbaMate(150767-02-5)
• EPA Substance Registry System: Tert-butyl N-[(4- Methoxyphenyl)MethylaMino]carbaMate(150767-02-5)

Safety Data

• Hazardous Substances Data: 150767-02-5(Hazardous Substances Data)

Usage

General Description

Tert-butyl N-[(4-Methoxyphenyl)MethylaMino]carbaMate is a chemical compound that belongs to the class of carbamates. It is a derivative of tert-butyl carbamate and contains a substituted methoxyphenylmethylamino group. Tert-butyl N-[(4- Methoxyphenyl)MethylaMino]carbaMate is commonly used in pharmaceutical research and drug development as it exhibits potential medicinal properties. Its structure and properties make it a valuable building block for the synthesis of new drugs, particularly those targeting the central nervous system. However, like all chemical compounds, it should be handled with care and its safety profile should be thoroughly evaluated before use in any practical applications.

Upstream product

• 150767-00-3 N-t-butoxycarbonyl-N'-4-methoxybenzaldehyde hydrazone 
• 870-46-2 t-butoxycarbonylhydrazine 
• 123-11-5 4-methoxy-benzaldehyde 
• 402723-13-1 p-(methoxyphenyl)-carbaldehyde tert-butoxycarbonylhydrazone 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 161852-67-1 N'-[(2S,3S)-2-Hydroxy-4-phenyl-3-(2,2,2-trifluoro-acetylamino)-butyl]-N'-(4-methoxy-benzyl)-hydrazinecarboxylic acid tert-butyl ester 
• 949556-61-0 1-(4-methoxybenzyl)-3-methyl-1H-pyrazol-5-amine 
• 1434003-97-0 tert-butyl 5-[2-azido-4-(ethoxycarbonyl)phenyl]-2-benzyl-3-isopropyl-2,3-dihydro-1H-pyrazole-1-carboxylate 
• 1372807-97-0 (S)-2-(4-methoxybenzyl)-4-(4-nitrobenzyl)-5-isobutyl-1,2,4-triazine-3,6-dione 
• 1372807-64-1 C₂₈H₃₈N₄O₈ 
• 1372807-96-9 (S)-2-(4-methoxybenzyl)-4-benzyl-5-isobutyl-[1,2,4]-triazine-3,6-dione 
• 1372807-63-0 C₂₈H₃₉N₃O₆ 
• 1372807-78-7 C₂₀H₂₉N₃O₆ 
• 412327-07-2 [(4-methoxyphenyl)methyl] hydrazine dihydrochloride 
• 161852-00-2 N'-((2S,3S)-3-{(S)-3-Carbamoyl-2-[(quinoline-2-carbonyl)-amino]-propionylamino}-2-hydroxy-4-phenyl-butyl)-N'-(4-methoxy-benzyl)-hydrazinecarboxylic acid tert-butyl ester 
• 161852-71-7 (S)-N¹-{(1S,2S)-1-Benzyl-2-hydroxy-3-[N-(4-methoxy-benzyl)-hydrazino]-propyl}-2-[(quinoline-2-carbonyl)-amino]-succinamide 
• 161852-68-2 N'-((2S,3S)-3-Amino-2-hydroxy-4-phenyl-butyl)-N'-(4-methoxy-benzyl)-hydrazinecarboxylic acid tert-butyl ester 
• 161852-56-8 N'-((2S,3S)-3-tert-Butoxycarbonylamino-2-hydroxy-4-phenyl-butyl)-N'-(4-methoxy-benzyl)-hydrazinecarboxylic acid tert-butyl ester 
• 150767-07-0 N'-((2S,3S)-3-Benzyloxycarbonylamino-2-hydroxy-4-phenyl-butyl)-N'-(4-methoxy-benzyl)-hydrazinecarboxylic acid tert-butyl ester 

Relevant articles and documents

Exploration of a Au(i)-mediated three-component reaction for the synthesis of DNA-tagged highly substituted spiroheterocycles

We demonstrate a Au(i)-mediated three-component reaction to DNA-tagged highly substituted 6-oxa-1,2-diazaspiro[4.4]nonanes from either DNA-coupled aldehydes, hydrazides, or alkynols. The choice of the starting material coupled to the DNA tag was critial for the purity of the product as the DNA-aldehyde conjugate yielded the purest products, whereas the alkynol- and hydrazide conjugates returned complex product mixtures. The reaction was compatible with thymine-, cytosine-, and, surprisingly, with adenine-DNA, while guanine-containing DNA strands were degraded under the reaction conditions.

Synthesis and biological evaluation of Hydrazone derivatives as antifungal agents

Emerging yeasts are among the most prevalent causes of systemic infections with high mortality rates and there is an urgent need to develop specific, effective and non-Toxic antifungal agents to respond to this issue. In this study 35 aldehydes, hydrazones and hydrazines were obtained and their antifungal activity was evaluated against Candida species (C. parapsilosis, C.Tropicalis, C. krusei, C. albicans, C. glabrata and C. lusitaneae) and Trichosporon asahii, in an in vitro screening. The minimum inhibitory concentrations (MICs) of the active compounds in the screening was determined against 10 clinical isolates of C. parapsilosis and 10 of T. asahii. The compounds 4-pyridin-2-ylbenzaldehyde] (13a) and tert-butyl-(2Z)-2-(3,4,5-Trihydroxybenzylidine)hydrazine carboxylate (7b) showed the most promising MIC values in the range of 16-32 μg/mL and 8-16 μg/mL, respectively. The compounds' action on the stability of the cell membrane and cell wall was evaluated, which suggested the action of the compounds on the fungal cell membrane. Cell viability of leukocytes and an alkaline comet assay were performed to evaluate the cytotoxicity. Compound 13a was not cytotoxic at the active concentrations. These results support the discovery of promising candidates for the development of new antifungal agents.

Combinatorial aid for underprivileged scaffolds: Solution and solid-phase strategies for a rapid and efficient access to novel aza-diketopiperazines (aza-DKP)

An efficient solution-phase synthesis of aza-diketopiperazines (aza-DKP, triazinediones) is reported. A structurally diverse collection of c-[aza-alkylGly-Pro] derivatives and yet unreported 2,4,5-trisubstituted-1,2,4- triazine-3,6-diones has been synthesized starting from Fmoc-l-Pro-OH and various Fmoc-l-amino acids. To extend the practical value of this class of dipeptidomimetics, a general solid-phase synthesis approach amenable to library production was developed on both Wang-PS and HMBA-PS resins. The final acidic treatment of the resins in TFA/water mixture at room temperature enabled the rapid and quantitative cyclization/release highly pure triazinediones. The conformational preferences and the spatial organization of the three substituents of a representative 2,4,5-trisubstituted-1,2,4-triazine-3,6-dione were investigated by X-ray diffraction and 1H NMR spectroscopy.