137281-77-7Relevant academic research and scientific papers
Rational design and synthesis of selective BACE-1 inhibitors
Brady, Stephen F.,Singh, Satendra,Crouthamel, Ming-Chih,Holloway, M. Katharine,Coburn, Craig A.,Garsky, Victor M.,Bogusky, Michael,Pennington, Michael W.,Vacca, Joseph P.,Hazuda, Daria,Lai, Ming-Tain
, p. 601 - 604 (2007/10/03)
An effective approach for enhancing the selectivity of β-site amyloid precursor protein cleaving enzyme (BACE 1) inhibitors is developed based on the unique features of the S1′ pocket of the enzyme. A series of low molecular weight (600) compounds were s
Potent small molecule CCR1 antagonists
Kath, John C.,Brissette, William H.,Brown, Matthew F.,Conklyn, Maryrose,DiRico, Amy P.,Dorff, Peter,Gladue, Ronald P.,Lillie, Brett M.,Lira, Paul D.,Mairs, Erin N.,Martin, William H.,McElroy, Eric B.,McGlynn, Molly A.,Paradis, Timothy J.,Poss, Christopher S.,Stock, Ingrid A.,Tylaska, Laurie A.,Zheng, Deye
, p. 2169 - 2173 (2007/10/03)
The present manuscript details structure-activity relationship studies of lead structure 1, which led to the discovery of CCR1 antagonists >100-fold more potent than 1.
Synthesis of a tripeptide derivative containing the Phe-Arg hydroxyethylene dipeptide isostere.
Brewer,Rich
, p. 945 - 948 (2007/10/03)
The protected hydroxyethylene dipeptide isostere of Phe-Arg and the tripeptide derivative 1 were synthesized as components of potential peptidase inhibitors. Key to the success of these syntheses is selective rhodium-catalyzed hydroboration in the presenc
