1372814-23-7Relevant articles and documents
Introducing the Chiral Constrained α-Trifluoromethylalanine in Aib Foldamers to Control, Quantify and Assign the Helical Screw-Sense**
Bodero, Lizeth,Brigaud, Thierry,Chaume, Grégory,Guitot, Karine,Lensen, Nathalie,Lequin, Olivier,Ongeri, Sandrine
, (2022/01/08)
Oligomers of α-aminoisobutyric acid (Aib) are achiral peptides that adopt 310 helical structures with equal population of left- and right-handed conformers. The screw-sense preference of the helical chain may be controlled by a single chiral re
Induction of unexpected left-handed helicity by an N-terminal L -amino acid in an otherwise achiral peptide chain
Brown, Robert A.,Marcelli, Tommaso,Depoli, Matteo,Sola, Jordi,Clayden, Jonathan
, p. 1395 - 1399 (2012/03/27)
Peptide helices containing L-amino acids are typically right-handed. Exceptions are peptide helices containing the achiral amino acids 2-aminoisobutyric acid and glycine with a single chiral amino acid at the Nterminus. These helices are left-handed when the N-terminal residue is a common tertiary proteinogenic amino acid, such as L-valine (see picture, left), but right-handed when the N-terminal residue is the quaternary amino acid L-α-methylvaline (right). Copyright
