1372814-30-6Relevant articles and documents
Induction of unexpected left-handed helicity by an N-terminal L -amino acid in an otherwise achiral peptide chain
Brown, Robert A.,Marcelli, Tommaso,Depoli, Matteo,Sola, Jordi,Clayden, Jonathan
, p. 1395 - 1399 (2012/03/27)
Peptide helices containing L-amino acids are typically right-handed. Exceptions are peptide helices containing the achiral amino acids 2-aminoisobutyric acid and glycine with a single chiral amino acid at the Nterminus. These helices are left-handed when the N-terminal residue is a common tertiary proteinogenic amino acid, such as L-valine (see picture, left), but right-handed when the N-terminal residue is the quaternary amino acid L-α-methylvaline (right). Copyright