1373162-73-2

Upstream product

• 91906-21-7 4-methoxythiophenoxylacetaldehyde dimethyl acetal 
• 696-63-9 4-Methoxybenzenethiol 
• 1373162-77-6 (R)-2-((benzo[b]thiophen-5-yloxy)methyl)oxirane 
• 1373162-81-2 (R)-1-(benzo[b]thiophen-5-yloxy)-3-(isobutylamino)propan-2-ol 
• 23095-31-0 3,4-dimethoxybenzene-1-sulfonyl chloride 
• 20532-30-3 5-methoxybenzothiophene 
• 19301-35-0 benzo[b]thiophen-5-ol 

Relevant academic research and scientific papers

Synthesis and biological evaluation of novel small non-peptidic HIV-1 PIs: The benzothiophene ring as an effective moiety

Synthesis and biological evaluation of a new series of potential HIV-1 protease inhibitors incorporating different heterocycles are described. The variation of heteroatom in such molecules has displayed totally different biological activities and a benzothiophene containing inhibitor has shown high potency against wild type HIV-1 protease with IC50 = 60 nM, thanks to the lower desolvation penalty to be payed by such hydrophobic moiety.