1373256-20-2

Upstream product

• 5382-16-1 4-HYDROXYPIPERIDINE 
• 86386-77-8 1-[2-(2,4-difluorophenyl)-2,3-epoxypropyl]-1H-1,2,4-triazole methanesulfonate 
• 372-18-9 1,3-Difluorobenzene 
• 51336-94-8 2-chloro-1-(2,4-dichlorophenyl)ethanone 
• 86386-76-7 1-[2-(2,4-difluorophenyl)-2,3-epoxypropyl]-1H-1,2,4-triazole 
• 86404-63-9 1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazolyl)ethanone 

Downstream Products

• 1373255-91-4 C₂₄H₂₆F₂N₄O₃ 
• 1395348-09-0 C₂₂H₂₃F₂N₅O₃ 
• 1373256-18-8 C₂₁H₂₂F₂N₄O₄ 
• 1373255-90-3 C₂₃H₂₃F₂IN₄O₃ 
• 1395347-93-9 C₂₃H₂₂Cl₂F₂N₄O₃ 
• 1395347-89-3 C₂₃H₂₃F₃N₄O₃ 
• 1395347-90-6 C₂₃H₂₃F₃N₄O₃ 
• 1395347-95-1 C₂₄H₂₆F₂N₄O₃ 
• 1395347-98-4 C₂₄H₂₆F₂N₄O₄ 
• 1395347-99-5 C₂₄H₂₆F₂N₄O₄ 
• 1373255-92-5 C₂₄H₂₆F₂N₄O₄ 
• 1395348-00-1 C₂₅H₂₈F₂N₄O₅ 
• 1373255-86-7 C₂₃H₂₄F₂N₄O₃ 
• 1395348-01-2 C₂₆H₃₀F₂N₄O₆ 

Relevant academic research and scientific papers

Design, synthesis and antifungal activity of novel triazole derivatives containing substituted 1,2,3-triazole-piperdine side chains

Due to increasing incidence of invasive fungal infections and severe drug resistance to triazole antifungal agents, a series of novel antifungal triazoles with substituted triazole-piperidine side chains were designed and synthesized. Most of the target compounds showed good inhibitory activity against a variety of clinically important fungal pathogens. In particular, compounds 8t and 8v were highly active against Candida albicans and Cryptococcus neoformans with MIC values in the range of 0.125 μg/mL to 0.0125 μg/mL. They represent promising leads for the development of new generation of triazole antifungal agents. Molecular docking studies revealed that the target compounds interacted with CACYP51 mainly through hydrophobic and Van der Waals interactions.

Synthesis and Biological Evaluation of Triazole Derivatives as Potential Antifungal Agent

A series of triazole antifungal agents with piperidine side chains were designed and synthesized. Results of preliminary antifungal tests against eight human pathogenic fungi in vitro showed that all the title compounds exhibited excellent activities with broad spectrum. Moreover, a molecular model for the binding between compound 12 and the active site of CACYP51 was provided based on the computational docking results. The side chain of the compound 12 is oriented into substrate access channel 2 (FG loop) and forms hydrophobic and van der waals interactions with surrounding hydrophobic residues. The phenyl group of the side chain can interact with the phenyl group of Phe380 through the formation of π-π face-to-edge interaction. A series of triazole antifungal agents with piperidine side chains were synthesized. And a molecular model for the binding between compound 12 and the active site of CACYP51 was provided based on the computational docking results.