137333-75-6

Upstream product

• 87184-81-4 4-(tert-butyldimethylsilanyloxy)butanal 
• 25333-24-8 3-benzoylpropionic acid methyl ester 
• 2051-95-8 succinylbenzene 
• 143878-46-0 1-phenyl-1-trimethylsilyloxy-4-t-butyldimethylsilyloxybutane 
• 4850-50-4 1-phenyl-butane-1,4-diol 
• 18162-48-6 tert-butyldimethylsilyl chloride 

Downstream Products

• 137333-76-7 1-phenyl-4-<(tert-butyldimethylsilyl)oxy>butyl dimethyl phosphite 
• 1283727-94-5 C₁₄H₁₆O₄ 
• 1283727-95-6 C₁₅H₂₀O₄ 
• 1283727-96-7 C₁₅H₁₉IO₃ 
• 1283728-08-4 (E)-methyl 3-(1-phenylbutoxy)acrylate 
• 1283728-10-8 (E)-methyl 3-(1-phenylbut-3-enyloxy)acrylate 
• 1283728-11-9 (2E,2'E)-dimethyl 3,3'-(1,8-diphenyloctane-1,8-diyl)bis(oxy)diacrylate 
• 1180131-45-6 C₁₆H₂₈OSi 
• 72064-43-8 tert-butyldimethylsilyl 4-phenylbutyl ether 

Relevant academic research and scientific papers

Chemo- and stereoselective six-membered oxonium ylide formation–[2,3]-sigmatropic rearrangement of 2-diazo-3-ketoesters with dirhodium(II) catalyst and its application to the synthesis of (+)-tanikolide

Dirhodium(II)-catalyzed oxonium ylide formation–[2,3]-sigmatropic rearrangement of 6-allyloxy-2-diazo-3-ketoesters possessing a C-6 substituent is described. The reaction of 6-alkyl- or 6-aryl-substituted 6-allyloxy-2-diazo-3-ketoesters with a catalytic amount of Rh2(S-PTTL)4 proceeded in a chemoselective and stereoselective manner to provide 6-substituted 2-allyl-3-oxotetrahydropyran-2-carboxylates in good yields and with high diastereoselectivities. To demonstrate the utility of this sequential reaction, we conducted the total synthesis of (+)-tanikolide, in which the construction of the δ-lactone skeleton was achieved by employing a 2-iodobenzamide-catalyzed oxidative cleavage of tetrahydropyran-2-methanol.

Chemoselective Deoxygenation of 2° Benzylic Alcohols through a Sequence of Formylation and B(C6F5)3-Catalyzed Reduction

A sequence of formylation and B(C6F5)3-catalyzed reduction of the resulting formate with Et3SiH enables the chemoselective deoxygenation of secondary benzylic alcohols. Primary benzylic and tertiary non-benzylic alcohols are not reduced by this protocol. The formyl group fulfills a double role as activator and self-sacrificing protecting group. The deoxygenation of these formates is fast and can be carried out in the presence of other potentially reducible groups. Neighboring-group participation was found in the deoxygenation of certain diol motifs.

Stereoselective construction of 2,6- cis -disubstituted tetrahydropyrans via intramolecular amide enolate alkylation: Total synthesis of (-)-centrolobine

A highly stereoselective construction of 2,6-cis-disubstituted tetrahydropyrans was achieved by using an intramolecular amide enolate alkylation with KHMDS. The efficiency and practicality of this methodology was successfully demonstrated in the total syn

Nickel-catalyzed reductive cyclization of organohalides

A mild and convenient nickel-catalyzed method for free-radical cyclization of organohalides is described. The use of a NiCl2DME/Pybox complex as the catalyst and zinc powder in methanol efficiently promotes the reductive cyclization of various

Bistriphenylsilanol-assisted oxidation catalyzed by chromium(VI) oxide of activated trimethyl ethers with tert-butyl hydroperoxide

Secondary benzylic or allylic trimetylsilyl ethers are oxidized at room temperature to the corresponding ketones in good yields using aqueous 70% t-BuOOH and catalytic amounts of a mixture of Ph3SiOH and CrO3.