1283728-08-4

Upstream product

• 137333-83-6 (+/-)-3-(t-butyldimethylsilanyloxy)-1-phenylpropan-1-ol 
• 4850-49-1 1-phenyl-1,3-propanediol 
• 614-27-7 methyl 3-oxo-3-phenylpropionate 
• 137333-75-6 4-tert-butyldimethylsilyloxy-1-phenylbutan-1-ol 
• 25333-24-8 3-benzoylpropionic acid methyl ester 
• 4850-50-4 1-phenyl-butane-1,4-diol 

Relevant academic research and scientific papers

Catalysis of Radical Cyclizations from Alkyl Iodides under H2: Evidence for Electron Transfer from [CpV(CO)3H]-

Radical cyclizations are most often achieved with Bu3SnH in the presence of a radical initiator, but environmental considerations demand that alternative reagents be developed - ones that can serve as a synthetic equivalent to the hydrogen atom. We have revisited [CpV(CO)3H]-, a known replacement for Bu3SnH, and found that it can be used catalytically under H2 in the presence of a base. We have carried out tin-free catalytic radical cyclizations of alkyl iodide substrates. The reactions are atom-efficient, and the conditions are mild, with broad tolerance for functional groups. We have, for example, achieved the first 5-exo radical cyclization involving attack onto a vinyl chloride. We suggest that the radicals are generated by an initial electron transfer.

Nickel-catalyzed reductive cyclization of organohalides

A mild and convenient nickel-catalyzed method for free-radical cyclization of organohalides is described. The use of a NiCl2DME/Pybox complex as the catalyst and zinc powder in methanol efficiently promotes the reductive cyclization of various