13734-66-2

Usage

Chemical structure

The compound consists of a ketone backbone (ethanone) with a bromophenyl group attached to the 2-position and a pyrrolidin-1-yl group attached to the 1-position.

Functional groups

The compound contains a carbonyl group (C=O) as the ketone functional group, a bromine atom as the halogen functional group, and a pyrrolidine ring as the nitrogen-containing heterocyclic functional group.

Physical properties

The physical properties of the compound are not provided in the material.

Chemical reactivity

The bromophenyl group can participate in halogenation reactions, and the pyrrolidin-1-yl group can participate in various organic reactions.

Uses

The compound is commonly used as a reagent in organic synthesis and pharmaceutical research, and may have potential applications in the development of new pharmaceuticals and agrochemicals.

Safety precautions

The compound may present health and safety hazards if not properly managed, so it is important to handle and use it with caution.

Upstream product

• 123-75-1 pyrrolidine 
• 1878-68-8 2-(4-bromophenyl)-acetic acid 
• 4030-18-6 N-(acetyl)pyrrolidine 
• 589-87-7 1,4-bromoiodobenzene 
• 37859-24-8 2-(4-bromophenyl)acetyl chloride 

Downstream Products

• 1022931-92-5 2-(4-bromo-2-fluorophenyl)-1-(pyrrolidin-1-yl)ethan-1-one 

Relevant academic research and scientific papers

Facile preparation of pyrimidinediones and thioacrylamides: Via reductive functionalization of amides

The development of an efficient protocol for the reductive functionalization of amides into pyrimidinediones and amino-substituted thioacrylamides is presented. Enamines are generated in a highly chemoselective amide hydrosilylation reaction catalyzed by

An Efficient One–pot Procedure for the Direct Preparation of 4,5-Dihydroisoxazoles from Amides

A Mo(CO)6 (molybdenumhexacarbonyl) catalyzed reductive functionalization of amides to afford 5-amino substituted 4,5-dihydroisoxazoles is presented. The reduction of amides generates reactive enamines, which upon the addition of hydroximinoyl chlorides and base undergoes a 1,3-dipolar cycloaddition reaction that gives access to the desired heterocyclic compounds. The transformation of amides is highly chemoselective and tolerates functional groups such as nitro, nitriles, esters, and ketones. Furthermore, a versatile scope of 4,5-dihydroisoxazoles derived from a variety of hydroximinoyl chlorides and amides is demonstrated. (Figure presented.).

A chemoselective Reformatsky-Negishi approach to α-haloaryl esters

A practical synthesis of α-haloaryl esters has been achieved via a chemoselective Negishi coupling of poly-halogenated aromatics and Reformatsky reagents in the presence of catalytic Pd(dba)2 and Xantphos. This chemistry tolerates a variety of aryl halides and was successfully applied to the synthesis of Ibuprofen. The α-haloaryl ester products, exemplified by ethyl 2-(4-bromo-2-chlorophenyl)acetate (3a), can be further functionalized via palladium or copper catalysis to afford an array of α-aryl esters.